| Tbio | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B |
Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway.
The MGAT5B gene encodes a beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.155) that functions in the synthesis of complex cell surface N-glycans (Kaneko et al., 2003 [PubMed 14623122]).[supplied by OMIM, Nov 2008]
The MGAT5B gene encodes a beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.155) that functions in the synthesis of complex cell surface N-glycans (Kaneko et al., 2003 [PubMed 14623122]).[supplied by OMIM, Nov 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Polycystic ovary syndrome | 360 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 2.2e-12 |
| ependymoma | 4679 | 2.3e-07 |
| Astrocytoma, Pilocytic | 3081 | 1.8e-06 |
| atypical teratoid / rhabdoid tumor | 5112 | 6.2e-06 |
| adult high grade glioma | 3801 | 6.6e-06 |
| glioblastoma | 5792 | 1.4e-05 |
| medulloblastoma, large-cell | 6241 | 1.5e-04 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Fukuyama congenital muscular dystrophy | 8 | 3.571 | 1.8 |
| Walker-Warburg syndrome | 20 | 3.072 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.900 | 6.6e-06 |
| Astrocytoma, Pilocytic | -1.600 | 1.8e-06 |
| atypical teratoid / rhabdoid tumor | -1.500 | 6.2e-06 |
| ependymoma | -1.200 | 2.3e-07 |
| glioblastoma | -1.100 | 1.4e-05 |
| medulloblastoma, large-cell | -1.800 | 1.5e-04 |
| ovarian cancer | 1.400 | 2.2e-12 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG |
MITVNPDGKIMVRRCLVTLRPFRLFVLGIGFFTLCFLMTSLGGQFSARRLGDSPFTIRTEVMGGPESRGV 1 - 70 LRKMSDLLELMVKRMDALARLENSSELHRAGGDLHFPADRMPPGAGLMERIQAIAQNVSDIAVKVDQILR 71 - 140 HSLLLHSKVSEGRRDQCEAPSDPKFPDCSGKVEWMRARWTSDPCYAFFGVDGTECSFLIYLSEVEWFCPP 141 - 210 LPWRNQTAAQRAPKPLPKVQAVFRSNLSHLLDLMGSGKESLIFMKKRTKRLTAQWALAAQRLAQKLGATQ 211 - 280 RDQKQILVHIGFLTEESGDVFSPRVLKGGPLGEMVQWADILTALYVLGHGLRVTVSLKELQSNLGVPPGR 281 - 350 GSCPLTMPLPFDLIYTDYHGLQQMKRHMGLSFKKYRCRIRVIDTFGTEPAYNHEEYATLHGYRTNWGYWN 351 - 420 LNPKQFMTMFPHTPDNSFMGFVSEELNETEKRLIKGGKASNMAVVYGKEASIWKLQGKEKFLGILNKYME 421 - 490 IHGTVYYESQRPPEVPAFVKNHGLLPQPEFQQLLRKAKLFIGFGFPYEGPAPLEAIANGCIFLQSRFSPP 491 - 560 HSSLNHEFFRGKPTSREVFSQHPYAENFIGKPHVWTVDYNNSEEFEAAIKAIMRTQVDPYLPYEYTCEGM 561 - 630 LERIHAYIQHQDFCRAPDPALPEAHAPQSPFVLAPNATHLEWARNTSLAPGAWPPAHALRAWLAVPGRAC 631 - 700 TDTCLDHGLICEPSFFPFLNSQDAFLKLQVPCDSTESEMNHLYPAFAQPGQECYLQKEPLLFSCAGSNTK 701 - 770 YRRLCPCRDFRKGQVALCQGCL 771 - 792 //
