Tdark METTL22 Methyltransferase-like protein 22

Protein Summary

Description

Protein N-lysine methyltransferase. In vitro methylates KIN. This gene encodes a member of the non-histone lysine methyltransferases. It interacts with its substrate, Kin17, which is involved in DNA repair and replication and mRNA processing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q9BUU2
• B2RD29
• D3DUF2
• Q6XYB4
• Q9HA03

Gene Name

• METTL22

Ensembl ID

• ENST00000163678
• ENSP00000163678
• ENSG00000067365
• ENST00000381920
• ENSP00000371345

Symbol

• C16orf68
• C16orf68

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.72
tissue sample	0.64
disease perturbation	0.62
cell line	0.59
tissue	0.54

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Methyltransferase-like Protein 22

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Methyltransferase-like Protein 22

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.03   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 31   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.03   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0