Tbio METRNL Meteorin-like protein

Protein Summary

Description

Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).

Uniprot Accession IDs

• Q641Q3
• B3KSJ5
• Q86VM0

Gene Name

• METRNL

Ensembl ID

• ENST00000320095
• ENSP00000315731
• ENSG00000176845
• ENST00000570778
• ENSP00000458566
• ENST00000571814
• ENSP00000460798
• ENST00000616599
• ENSP00000481759
• ENSG00000275031
• ENST00000633913
• ENSP00000488860
• ENST00000634158
• ENSP00000488881

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
virus perturbation	0.94
transcription factor perturbation	0.74
transcription factor	0.65
PubMedID	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.17   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 94   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.17   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0