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Tdark Meteorin-like protein

Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).

 Comments

Property Summary

NCBI Gene PubMed Count 5
PubMed Score 7.02
PubTator Score 4.13

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Actinic keratosis 22 3.067 1.5

Expression

  Differential Expression (9)

Disease log2 FC p
osteosarcoma 1.771 7.5e-03
medulloblastoma, large-cell -2.000 7.8e-05
primary pancreatic ductal adenocarcinoma 1.529 6.7e-03
tuberculosis -1.500 2.1e-03
inflammatory breast cancer 1.100 2.2e-02
gastric carcinoma 1.300 4.0e-02
ovarian cancer 3.300 7.0e-08
pituitary cancer -2.700 1.2e-06
pancreatic cancer 1.900 6.0e-03

Synonym

Accession Q641Q3 B3KSJ5 Q86VM0
Symbols

Gene

METRNL

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (6)

 GO Function (1)

 GO Component (2)

 GO Process (7)

 Compartment GO Term (11)

 IMPC Phenotype (4)

 MGI Phenotype (1)

 HCA RNA Cell Line (56)

See all...

Pathway (1)

Gene RIF (2)

PMID Text
26307585 Data suggest that there is no correlation between serum Metrnl levels and BMI (body mass index) in humans.
24393292 Results show that Subfatin is a novel adipokine regulated by adipogenesis and obesity, with tissue distribution different from its homologue Meteorin

AA Sequence 

MRGAARAAWGRAGQPWPRPPAPGPPPPPLPLLLLLLAGLLGGAGAQYSSDRCSWKGSGLTHEAHRKEVEQ      1 - 70
VYLRCAAGAVEWMYPTGALIVNLRPNTFSPARHLTVCIRSFTDSSGANIYLEKTGELRLLVPDGDGRPGR     71 - 140
VQCFGLEQGGLFVEATPQQDIGRRTTGFQYELVRRHRASDLHELSAPCRPCSDTEVLLAVCTSDFAVRGS    141 - 210
IQQVTHEPERQDSAIHLRVSRLYRQKSRVFEPVPEGDGHWQGRVRTLLECGVRPGHGDFLFTGHMHFGEA    211 - 280
RLGCAPRFKDFQRMYRDAQERGLNPCEVGTD                                           281 - 311
//

Text Mined References (8)

PMID Year Title
26307585 2015 Adipocyte Metrnl Antagonizes Insulin Resistance Through PPAR? Signaling.
24906147 2014 Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.
24393292 2014 Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression.
19199708 2009 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
16625196 2006 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.