| Tbio | Meteorin-like protein |
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 7.0e-08 |
| pituitary cancer | 1972 | 1.2e-06 |
| medulloblastoma, large-cell | 6241 | 7.8e-05 |
| Breast cancer | 3578 | 1.1e-04 |
| tuberculosis | 2010 | 2.1e-03 |
| pancreatic cancer | 2398 | 6.0e-03 |
| primary pancreatic ductal adenocarcinoma | 1109 | 6.7e-03 |
| osteosarcoma | 7950 | 7.5e-03 |
| gastric carcinoma | 807 | 4.0e-02 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | 1.100 | 1.1e-04 |
| gastric carcinoma | 1.300 | 4.0e-02 |
| medulloblastoma, large-cell | -2.000 | 7.8e-05 |
| osteosarcoma | 1.771 | 7.5e-03 |
| ovarian cancer | 3.300 | 7.0e-08 |
| pancreatic cancer | 1.900 | 6.0e-03 |
| pituitary cancer | -2.700 | 1.2e-06 |
| primary pancreatic ductal adenocarcinoma | 1.529 | 6.7e-03 |
| tuberculosis | -1.500 | 2.1e-03 |
MRGAARAAWGRAGQPWPRPPAPGPPPPPLPLLLLLLAGLLGGAGAQYSSDRCSWKGSGLTHEAHRKEVEQ 1 - 70 VYLRCAAGAVEWMYPTGALIVNLRPNTFSPARHLTVCIRSFTDSSGANIYLEKTGELRLLVPDGDGRPGR 71 - 140 VQCFGLEQGGLFVEATPQQDIGRRTTGFQYELVRRHRASDLHELSAPCRPCSDTEVLLAVCTSDFAVRGS 141 - 210 IQQVTHEPERQDSAIHLRVSRLYRQKSRVFEPVPEGDGHWQGRVRTLLECGVRPGHGDFLFTGHMHFGEA 211 - 280 RLGCAPRFKDFQRMYRDAQERGLNPCEVGTD 281 - 311 //
