Property Summary

NCBI Gene PubMed Count 14
PubMed Score 3.60
PubTator Score 12.48

Knowledge Summary


No data available


  Disease (1)


  Differential Expression (4)

Disease log2 FC p
hepatocellular carcinoma 1.300 5.5e-05
osteosarcoma 1.404 1.4e-03
tuberculosis and treatment for 6 months -1.100 7.2e-05
lung cancer 1.800 9.9e-04

Gene RIF (2)

25446406 We identified the first and homozygous mutation (p.Gly114Ala) in the Mediator subunit 20 gene (MED20) in siblings presenting with infantile-onset spasticity and childhood-onset dystonia, progressive basal ganglia degeneration, and brain atrophy
18976975 Knockdown of mediator complex subunit 20 (MED20) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells

AA Sequence

IR                                                                        211 - 212

Text Mined References (17)

PMID Year Title
25446406 2015 MED20 mutation associated with infantile basal ganglia degeneration and brain atrophy.
25416956 2014 A proteome-scale map of the human interactome network.
24101134 2013 Gene expression profile of the whole Mediator complex in human osteosarcoma and normal osteoblasts.
23263863 2013 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
21269460 2011 Initial characterization of the human central proteome.
20139978 2010 Genome-wide association study of hematological and biochemical traits in a Japanese population.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
15989967 2005 MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15175163 2004 A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14576168 2003 A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.
14574404 2003 The DNA sequence and analysis of human chromosome 6.
12838346 2003 Human and mouse proteases: a comparative genomic approach.
12584197 2003 Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9933582 1999 The human homologue of Drosophila TRF-proximal protein is associated with an RNA polymerase II-SRB complex.