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Tbio
MED1
Mediator of RNA polymerase II transcription subunit 1

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These fac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300651
  • ENSP00000300651
  • ENSG00000125686
  • ENST00000394287
  • ENSP00000377828

Symbol
  • ARC205
  • CRSP1
  • CRSP200
  • DRIP205
  • DRIP230
  • PBP
  • PPARBP
  • PPARGBP
  • RB18A
  • TRAP220
  • TRIP2
  • PBP
  • CRSP1
  • RB18A
  • TRIP2
  • PPARBP
  • CRSP200
  • DRIP205
  • DRIP230
  • PPARGBP
  • TRAP220
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
disease perturbation
0.97
interacting protein
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.39   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 458   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.39   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 458   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 78
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0