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Tchem NADP-dependent malic enzyme

This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

Ligand Count 3
NCBI Gene PubMed Count 35
PubMed Score 92.84
PubTator Score 819.57

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count Z-score Confidence
Carcinoma, Hepatocellular 228 0.0 0.0
Obesity 678 0.0 0.0
Weight Gain 100 0.0 0.0
Disease Target Count
Liver carcinoma 240
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.0
Kidney cancer 2613 0.0 0.5

Expression

  Differential Expression (29)

Disease log2 FC p
active Crohn's disease 1.886 3.9e-02
active ulcerative colitis 2.788 2.8e-02
acute quadriplegic myopathy 1.069 2.2e-03
adult high grade glioma -1.600 1.8e-02
Amyotrophic lateral sclerosis 1.171 7.6e-05
astrocytic glioma -3.000 5.8e-03
Atopic dermatitis -1.400 3.1e-03
atypical teratoid / rhabdoid tumor -3.700 1.6e-06
Breast cancer 1.300 8.1e-03
breast carcinoma -1.600 2.4e-03
colon cancer 1.700 3.3e-02
ductal carcinoma in situ -1.800 2.7e-02
ependymoma -3.000 3.9e-02
fibroadenoma -2.200 2.6e-02
glioblastoma -1.700 4.5e-02
group 3 medulloblastoma -2.800 6.2e-04
intraductal papillary-mucinous adenoma (... 1.400 4.0e-02
intraductal papillary-mucinous carcinoma... 1.700 9.6e-03
lung cancer 2.500 2.1e-05
medulloblastoma, large-cell -3.800 8.7e-07
mucosa-associated lymphoid tissue lympho... 2.888 3.8e-02
nasopharyngeal carcinoma -1.100 2.8e-02
oligodendroglioma -2.300 2.7e-02
osteosarcoma 2.086 3.3e-03
ovarian cancer -3.400 2.3e-14
primitive neuroectodermal tumor -2.000 7.0e-03
psoriasis 1.100 2.9e-03
Rheumatoid arthritis 1.700 6.4e-03
tuberculosis and treatment for 3 months -1.100 1.1e-02

Synonym

Accession P48163 B4DZ70 Q16797 Q16855 Q53F72 Q5VWA2 Q9BWX8 Q9H1W3 Q9UIY4 NADP-ME
Symbols MES
HUMNDME

Gene

ME1

PANTHER Protein Class (2)

PDB

2AW5   3WJA  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (10)

 GO Function (9)

 GO Component (2)

 GO Process (9)

 Compartment GO Term (17)

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 MGI Phenotype (3)

 GWAS Trait (2)

 HCA RNA Cell Line (56)

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Pathway (25)

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Ligand (3)

Structure of CHEMBL202332

CHEMBL202332
pIC50 6.25

Structure of CHEMBL201911

CHEMBL201911
pIC50 6.35

Structure of CHEMBL372408

CHEMBL372408
pIC50 6.82

Gene RIF (16)

AA Sequence 

MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFD      1 - 70
RYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAW     71 - 140
PEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLKDPLYIG    141 - 210
LRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAG    211 - 280
LLAALRITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQE    281 - 350
KEKFAHEHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQC    351 - 420
YKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLTTAEVIAQQVS    421 - 490
DKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFVRSQMYSTDYDQILPDCYSWP    491 - 560
EEVQKIQTKVDQ                                                              561 - 572
//

Text Mined References (38)

PMID Year Title