Tbio MCM7 DNA replication licensing factor MCM7

Protein Summary

Description

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P33993
• A4D2A1
• A4D2A2
• E9PGN9
• Q15076
• Q96D34
• Q96GL1

Gene Name

• MCM7

Ensembl ID

• ENST00000303887
• ENSP00000307288
• ENSG00000166508
• ENST00000343023
• ENSP00000344006
• ENST00000354230
• ENSP00000346171
• ENST00000621318
• ENSP00000483795

Symbol

• CDC47
• MCM2
• MCM2
• CDC47
• P85MCM
• P1CDC47
• PNAS146
• PPP1R104
• P1.1-MCM3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus	1
kinase perturbation	0.99
molecular function	0.99
transcription factor perturbation	0.99
viral protein	0.98

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / Dna Replication Licensing Factor Mcm7

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / Dna Replication Licensing Factor Mcm7

Protein / Hydrolase / Dna Replication Licensing Factor Mcm7

DTO Classes

Protein / Enzyme / Helicase / Dna Helicase / Dna Replication Licensing Factor Mcm7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 678.69   (req: < 5)

Gene RIFs: 87   (req: <= 3)

Antibodies: 1074   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 678.69   (req: >= 5)

Gene RIFs: 87   (req: > 3)

Antibodies: 1074   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0