| Tchem | Melanocortin receptor 3 |
This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 81 |
| NCBI Gene PubMed Count | 94 |
| PubMed Score | 445.30 |
| PubTator Score | 208.70 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 9 | 1 | 0.0 | 0.0 |
| MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO | 11 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding) | 11 |
| Disease | Target Count |
|---|---|
| Erythropoietic protoporphyria | 15 |
| Exacerbation of multiple sclerosis | 2 |
| Stevens-Johnson syndrome | 92 |
| West Syndrome | 28 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Tricuspid valve insufficiency | 14 | 5.23 | 2.6 |
| Mucoepidermoid carcinoma | 26 | 4.589 | 2.3 |
| Disease | Target Count |
|---|---|
| Obesity | 678 |
| Obesity due to MC3R deficiency | 1 |
CHEMBL3421678
pIC50 7.00
CHEMBL2113041
pIC50 7.01
CHEMBL214347
pKi 7.07
CHEMBL187990
pIC50 7.08
CHEMBL411391
pIC50 7.08
CHEMBL446757
pKi 7.10
CHEMBL91041
pKi 7.11
CHEMBL443396
pKi 7.12
CHEMBL378837
pKi 7.13
CHEMBL313690
pEC50 7.13
CHEMBL2070374
pKi 7.15
CHEMBL432377
pEC50 7.16
CHEMBL2070247
pKi 7.17
CHEMBL433413
pEC50 7.17
CHEMBL413565
pKi 7.18
CHEMBL89004
pKi 7.18
CHEMBL432565
pKi 7.19
CHEMBL333178
pKi 7.25
CHEMBL415333
pKi 7.27
CHEMBL209789
pKi 7.30
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLH 1 - 70 SPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAV 71 - 140 DRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHM 141 - 210 FLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAH 211 - 280 FNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG 281 - 323 //
