You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MATK
Megakaryocyte-associated tyrosine-protein kinase

Protein Summary
Description
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Thr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310132
  • ENSP00000308734
  • ENSG00000007264
  • ENST00000395040
  • ENSP00000378481
  • ENST00000395045
  • ENSP00000378485
  • ENST00000619596
  • ENSP00000483213

Symbol
  • CTK
  • HYL
  • CHK
  • CTK
  • HYL
  • Lsk
  • HYLTK
  • HHYLTK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.94
small molecule perturbation
0.65
disease perturbation
0.56
disease
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1987.23   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1987.23   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0