MAT2B
Methionine adenosyltransferase 2 subunit beta
Protein Summary
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
- ENST00000280969
- ENSP00000280969
- ENSG00000038274
- ENST00000321757
- ENSP00000325425
- ENST00000518095
- ENSP00000428046
- TGR
- TGR
- MAT-II
- SDR23E1
- MATIIbeta
- Nbla02999
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.94 | ||
kinase perturbation | 0.93 | ||
virus perturbation | 0.85 | ||
transcription factor binding site profile | 0.82 | ||
transcription factor | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.71 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 219 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.71 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 219 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0