Tchem MARK3 MAP/microtubule affinity-regulating kinase 3

Protein Summary

Description

Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• P27448
• A0A0A0MQR8
• A0A0A0MST9
• A0A0A0MT23
• O60219
• Q86TT8
• Q8TB41
• Q8WX83
• Q96RG1
• Q9UMY9
• Q9UN34

Gene Name

• MARK3

Ensembl ID

• ENST00000216288
• ENSP00000216288
• ENSG00000075413
• ENST00000303622
• ENSP00000303698
• ENST00000416682
• ENSP00000408092
• ENST00000429436
• ENSP00000411397
• ENST00000440884
• ENSP00000402104
• ENST00000553942
• ENSP00000450772

Symbol

• CTAK1
• EMK2
• KP78
• VIPB
• CTAK1
• PAR1A
• Par-1a

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
disease perturbation	0.98
protein domain	0.97
interacting protein	0.93
molecular function	0.91

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Map/microtubule Affinity-regulating Kinase 3

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Camkl Family / Mark Subfamily / Map/microtubule Affinity-regulating Kinase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.27   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 418   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.27   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 418   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 43

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1