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Tbio
MARCH8
E3 ubiquitin-protein ligase MARCH8

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS. MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319836
  • ENSP00000317087
  • ENSG00000165406
  • ENST00000395769
  • ENSP00000379116
  • ENST00000395771
  • ENSP00000379118
  • ENSG00000278545
  • ENST00000453424
  • ENSP00000411848

Symbol
  • MIR
  • RNF178
  • MIR
  • CMIR
  • c-MIR
  • RNF178
  • MARCH-VIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor perturbation
0.8
virus perturbation
0.76
phenotype
0.72
cellular component
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.62   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.62   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0