Tbio MARC1 Mitochondrial amidoxime-reducing component 1

Protein Summary

Description

As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.

Uniprot Accession IDs

• Q5VT66
• A8K447
• B2D078
• Q5VVS9
• Q5VVT0
• Q5VVT1
• Q8N9P5
• Q96FN8
• Q9H6C7
• mARC1

Gene Name

• MARC1

Ensembl ID

• ENST00000366910
• ENSP00000355877
• ENSG00000186205

Symbol

• MOSC1
• MOSC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.92
tissue sample	0.66
cellular component	0.65
cell type or tissue	0.64
histone modification site profile	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.32   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 106   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.32   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0