Tbio MAPRE2 Microtubule-associated protein RP/EB family member 2

Protein Summary

Description

May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity). The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• Q15555
• B2RE21
• B3KR39
• B4DJV4
• B7Z2L3
• E9PHR3
• F5H1V8
• G5E9I6
• Q9UQ33

Gene Name

• MAPRE2

Ensembl ID

• ENST00000300249
• ENSP00000300249
• ENSG00000166974
• ENST00000413393
• ENSP00000396074
• ENST00000436190
• ENSP00000407723
• ENST00000538170
• ENSP00000446343
• ENST00000588910
• ENSP00000468588
• ENST00000589699
• ENSP00000464921

Symbol

• RP1
• EB1
• EB2
• RP1
• CSCSC2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
transcription factor	0.89
trait	0.75
PubMedID	0.68
small molecule perturbation	0.67

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Microtubule-associated Protein Rp/eb Family Member 2

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Microtubule-associated Protein Rp/eb Family Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.36   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 354   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.36   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0