Tbio MAPKAP1 Target of rapamycin complex 2 subunit MAPKAP1

Protein Summary

Description

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BPZ7
• A8K1Z5
• B1AMA4
• B7Z309
• Q00426
• Q5JSV5
• Q5JSV6
• Q5JSV9
• Q658R0
• Q699U1
• Q699U2
• Q699U3
• Q699U4
• Q6GVJ0
• Q6GVJ1
• Q6GVJ2
• TORC2 subunit MAPKAP1

Gene Name

• MAPKAP1

Ensembl ID

• ENST00000265960
• ENSP00000265960
• ENSG00000119487
• ENST00000350766
• ENSP00000265961
• ENST00000373498
• ENSP00000362597
• ENST00000373503
• ENSP00000362602
• ENST00000373511
• ENSP00000362610
• ENST00000394060
• ENSP00000377624
• ENST00000394063
• ENSP00000377627

Symbol

• MIP1
• SIN1
• MIP1
• SIN1
• JC310
• SIN1b
• SIN1g

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
disease perturbation	0.83
transcription factor perturbation	0.8
virus perturbation	0.79
molecular function	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.99   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 294   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.99   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0