Tbio MAP4 Microtubule-associated protein 4

Protein Summary

Description

Non-neuronal microtubule-associated protein. Promotes microtubule assembly. The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Uniprot Accession IDs

• P27816
• Q13082
• Q59FT2
• Q68D74
• Q6ZUW9
• Q86V26
• Q96A76
• Q96NS9
• MAP-4

Gene Name

• MAP4

Ensembl ID

• ENST00000360240
• ENSP00000353375
• ENSG00000047849
• ENST00000395734
• ENSP00000379083
• ENST00000434267
• ENSP00000402767
• ENST00000439356
• ENSP00000397414

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
ligand (protein) perturbation	1
disease perturbation	0.97
microRNA	0.97
kinase perturbation	0.93

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 282.71   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 336   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 282.71   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0