Tbio MAP3K21 Mitogen-activated protein kinase kinase kinase 21

Protein Summary

Description

Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

Uniprot Accession IDs

• Q5TCX8
• A0A1W2PKR9
• B2RN34
• Q5TCX7
• Q5TCX9
• Q8WWN1
• Q8WWN2
• Q96JM1
• X6R610

Gene Name

• MAP3K21

Ensembl ID

• ENST00000366622
• ENSP00000355581
• ENSG00000143674
• ENST00000366623
• ENSP00000355582
• ENST00000366624
• ENSP00000355583

Symbol

• KIAA1804
• MLK4
• MLK4
• dJ862P8.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Mlk Family / Mitogen-activated Protein Kinase Kinase Kinase Mlk4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.37   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.37   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0