Tchem MAP3K15 Mitogen-activated protein kinase kinase kinase 15

Protein Summary

Description

May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis. The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q6ZN16
• A2AI49
• A2AI50
• A6NJ61
• Q5JPR4
• Q6ZMV3

Gene Name

• MAP3K15

Ensembl ID

• ENST00000338883
• ENSP00000345629
• ENSG00000180815

Symbol

• ASK3
• ASK3
• bA723P2.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.97
protein domain	0.92
tissue sample	0.72
cell line	0.61
phenotype	0.6

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste11 Family / Mitogen-activated Protein Kinase Kinase Kinase 15

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.73   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.73   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0