MAP3K14
Mitogen-activated protein kinase kinase kinase 14
Protein Summary
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner. This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]
- ENST00000344686
- ENSP00000478552
- ENSG00000006062
- ENST00000376926
- ENSP00000482657
- ENST00000648527
- ENSP00000497704
- NIK
- HS
- NIK
- HSNIK
- FTDCR1B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
molecular function | 0.98 | ||
transcription factor binding site profile | 0.88 | ||
biological process | 0.79 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.76 (req: < 5)
Gene RIFs: 79 (req: <= 3)
Antibodies: 318 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.76 (req: >= 5)
Gene RIFs: 79 (req: > 3)
Antibodies: 318 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 495
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0