Tchem MAP3K10 Mitogen-activated protein kinase kinase kinase 10

Protein Summary

Description

Activates the JUN N-terminal pathway. The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q02779
• Q12761
• Q14871

Gene Name

• MAP3K10

Ensembl ID

• ENST00000253055
• ENSP00000253055
• ENSG00000130758

Symbol

• MLK2
• MST
• MST
• MLK2
• MEKK10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.97
biological process	0.9
histone modification site profile	0.86
hub protein	0.75

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Mlk Family / Mlk Subfamily / Mitogen-activated Protein Kinase Kinase Kinase 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.09   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 254   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.09   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1