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Tbio Alpha-mannosidase 2x

Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

 Comments

Property Summary

NCBI Gene PubMed Count 6
PubMed Score 8.81
PubTator Score 2.92

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.0
Disease Target Count Z-score Confidence
Attention deficit hyperactivity disorder 278 0.0 1.7

Expression

  Differential Expression (8)

Disease log2 FC p
Breast cancer -2.100 2.8e-02
invasive ductal carcinoma -1.400 1.2e-03
non-small cell lung cancer -1.244 1.8e-28
osteosarcoma -1.903 1.7e-05
Pick disease -1.300 9.1e-05
posterior fossa group A ependymoma -1.100 8.2e-12
psoriasis -1.100 2.9e-07
subependymal giant cell astrocytoma -1.541 5.8e-03

Synonym

Accession P49641 A6NH12 A8K1E8 Q13754
Symbols MANA2X

Gene

MAN2A2

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (15)

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 GO Function (5)

 GO Component (2)

 GO Process (4)

 Compartment GO Term (23)

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 MGI Phenotype (6)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (13)

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Gene RIF (20)

AA Sequence 

MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPTRHQNGGNFPRSQISVLQNRIEQLEQLLEENHEIISH      1 - 70
IKDSVLELTANAEGPPAMLPYYTVNGSWVVPPEPRPSFFSISPQDCQFALGGRGQKPELQMLTVSEELPF     71 - 140
DNVDGGVWRQGFDISYDPHDWDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRR    141 - 210
FLWAEVSFFAKWWDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGA    211 - 280
TPRSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMP    281 - 350
FYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLFRSNVLL    351 - 420
VPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPGARPPGFPVLS    421 - 490
GDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHARRSGLAGRYPLSDFTLLTEAR    491 - 560
RTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHAAHYLVLGDKETYHFDPEAPFLQVDDTRL    561 - 630
SHDALPERTVIQLDSSPRFVVLFNPLEQERFSMVSLLVNSPRVRVLSEEGQPLAVQISAHWSSATEAVPD    631 - 700
VYQVSVPVRLPALGLGVLQLQLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDFALSNRYM    701 - 770
QVWFSGLTGLLKSIRRVDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGPF    771 - 840
FSEVVAYYEHIHQAVRLYNLPGVEGLSLDISSLVDIRDYVNKELALHIHTDIDSQGIFFTDLNGFQVQPR    841 - 910
RYLKKLPLQANFYPMPVMAYIQDAQKRLTLHTAQALGVSSLKDGQLEVILDRRLMQDDNRGLGQGLKDNK    911 - 980
RTCNRFRLLLERRTVGSEVQDSHSTSYPSLLSHLTSMYLNAPALALPVARMQLPGPGLRSFHPLASSLPC    981 - 1050
DFHLLNLRTLQAEEDTLPSAETALILHRKGFDCGLEAKNLGFNCTTSQGKVALGSLFHGLDVVFLQPTSL   1051 - 1120
TLLYPLASPSNSTDVYLEPMEIATFRLRLG                                           1121 - 1150
//

Text Mined References (9)

PMID Year Title