Property Summary

NCBI Gene PubMed Count 17
PubMed Score 84.68
PubTator Score 157.59

Knowledge Summary


No data available


  Differential Expression (11)


Accession Q9H213 B2R8V9 Q5JRJ3 Q9Y5M2
Symbols APR1


PANTHER Protein Class (1)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (3)

26572808 our data showed that Apr-1 plays a crucial role in cell proliferation by controlling cell cycle progression, implying a tumor-suppressor function of Apr-1 in cholangiocarcinoma carcinogenesis
25366798 Data indicate that the neonatal detection test sensitivity obtained was 95% with a positive predictive value of 1 in the analyses for both the arylsulfatase E (ARSE) and melanoma antigen family H1 (MAGEH1) genes.
21418516 The induction of APR-1 expression caused apoptosis of melanoma cells via the interaction with the juxtamembrane region of p75 neurotrophin receptor.

AA Sequence

SGARGYSAP                                                                 211 - 219

Text Mined References (18)

PMID Year Title
26572808 2016 Apoptosis-related protein-1 acts as a tumor suppressor in cholangiocarcinoma cells by inducing cell cycle arrest via downregulation of cyclin-dependent kinase subunits.
25416956 2014 A proteome-scale map of the human interactome network.
25366798 2014 Neonatal detection of Turner syndrome by real-time PCR gene quantification of the ARSE and MAGEH1 genes.
24665060 2014 Genome-wide association study of smoking behaviours among Bangladeshi adults.
21418516 2012 Apoptosis related protein-1 triggers melanoma cell death via interaction with the juxtamembrane region of p75 neurotrophin receptor.
20088962 2010 Establishment of six new human biliary tract carcinoma cell lines and identification of MAGEH1 as a candidate biomarker for predicting the efficacy of gemcitabine treatment.
18759029 2002 Cloning and biological comparison of Restin, novel member of Mage superfamily.
16574066 2006 Transcriptional up-regulation of restin by all-trans retinoic acid through STAT1 in cancer cell differentiation process.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15772651 2005 The DNA sequence of the human X chromosome.
15694019 2005 [Cloning and subcellular localization of apr-1--a new gene of tumor specific antigen family].
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15383276 2004 A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12414813 2002 The p75 neurotrophin receptor interacts with multiple MAGE proteins.
11454705 2001 An overview of the MAGE gene family with the identification of all human members of the family.
10948432 2000 Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes.