Tdark MAGEB6 Melanoma-associated antigen B6

Protein Summary

Description

This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is expressed in testis, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8N7X4
• Q6GS19
• Q9H219

Gene Name

• MAGEB6

Ensembl ID

• ENST00000379034
• ENSP00000368320
• ENSG00000176746

Symbol

• CT3.4
• MAGE-B6
• MAGEB6A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.47
microRNA	0.43
protein complex	0.42
cell type or tissue	0.41
tissue sample	0.38

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Melanoma-associated Antigen B6

DTO Classes

Protein / Cell Adhesion / Melanoma-associated Antigen B6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.31   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 81   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.31   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0