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Tbio Leucine zipper putative tumor suppressor 2

Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.

The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

 Comments

Property Summary

NCBI Gene PubMed Count 30
PubMed Score 8.29
PubTator Score 6.91

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
atypical teratoid / rhabdoid tumor 5112 4.5e-04
glioblastoma 5792 1.8e-03
medulloblastoma, large-cell 6241 1.9e-02
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.6

Expression

  Differential Expression (3)

Disease log2 FC p
atypical teratoid / rhabdoid tumor 1.100 4.5e-04
glioblastoma 1.100 1.8e-03
medulloblastoma, large-cell 1.100 1.9e-02

Synonym

Accession Q9BRK4 B1AL14 D3DR72 Q8N3I0 Q96J79 Q96JL2 hLZTS2
Symbols LAPSER1

Gene

LZTS2

  Ortholog (1)

Species Source Disease
Macaque OMA EggNOG Inparanoid

 UniProt Keyword (12)

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 GO Component (5)

 GO Process (7)

 Compartment GO Term (28)

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 MGI Phenotype (4)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Protein-protein Interaction (55)

ACAD11   MYO9A   ASPM   RECQL4   DYRK1B   DYRK1A   ZNF324   ELOA   LZTS1   SIPA1L1   SMC2   CRNKL1   ISCA1   SBF1   NCAPD3   SIPA1L2   ZMYM6   PIP4K2C   PIP4K2B   PIP4K2A   ERCC3   NBN   KIF7   C2CD5   AMPD2   SOGA1   SSX2IP   NUDT15   CCDC12   ZNF644   SESTD1   NCAPH2   HIC2   CPSF4   WDR33   PLCG1   ZMYM1   EAPP   CEP290   AGAP1   AGAP3   TTC31   GTF2H1   CEP131   MIS18BP1   SIPA1L3   APC   TTLL4   CD3EAP   CTC1   RAB11FIP5   TSSC4   TROAP   POLR1E   HIPK2  

Gene RIF (7)

AA Sequence 

MAIVQTLPVPLEPAPEAATAPQAPVMGSVSSLISGRPCPGGPAPPRHHGPPGPTFFRQQDGLLRGGYEAQ      1 - 70
EPLCPAVPPRKAVPVTSFTYINEDFRTESPPSPSSDVEDAREQRAHNAHLRGPPPKLIPVSGKLEKNMEK     71 - 140
ILIRPTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLAFSGWAS    141 - 210
GCPSGTLSDSGRNSLSSLPTYSTGGAEPTTSSPGGHLPSHGSGRGALPGPARGVPTGPSHSDSGRSSSSK    211 - 280
STGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDEN    281 - 350
EATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLER    351 - 420
RCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEG    421 - 490
RARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKV    491 - 560
QRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQ    561 - 630
LEQELQQLSLELEARELADLGLAEQAPCICLEEITATEI                                   631 - 669
//

Text Mined References (36)

PMID Year Title