Property Summary

NCBI Gene PubMed Count 25
PubMed Score 26.81
PubTator Score 23.85

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (11)

Disease log2 FC p
esophageal adenocarcinoma -3.300 2.0e-02
adrenocortical carcinoma -1.068 1.5e-05
tuberculosis -1.700 1.8e-06
non-small cell lung cancer 2.727 2.7e-13
interstitial cystitis -2.000 4.3e-04
cystic fibrosis 1.200 1.3e-02
nasopharyngeal carcinoma -1.200 1.2e-02
spina bifida -1.544 3.7e-02
ductal carcinoma in situ 1.100 3.4e-02
invasive ductal carcinoma 1.500 2.6e-02
ovarian cancer 1.400 2.0e-08

Gene RIF (12)

PMID Text
25414274 expression of the Ly6/uPAR-domain proteins C4.4A and Haldisin in non-invasive and invasive skin lesions
24935570 overexpression of C4.4A correlates with metastatic potential of gastric cancer and C4.4A could be a novel independent prognostic marker for predicting outcome.
23918676 Highly expressed C4.4A protein in HER2-positive human breast cancers indicate a good prognosis.
23708783 Tenascin-C expression was significantly associated with C4.4A expression in clinical esophageal squamous carcinoma samples suggesting that there may be a functional role for the C4.4A to induceTenascin-C in vivo.
22431918 the first explanation for the C4.4A contribution to wound healing and metastasis.
22404718 findings suggest that a tight association between C4.4A and tumor budding may, in part, be due to C4.4A promoting epithelial-mesenchymal transition at the invasive front of colorectal cancer
20825414 data indicate that expression of the C4.4A protein at the invasive front acts as a novel prognostic marker in colorectal cancer, possibly through invasion-related mechanisms
18979631 cleavage of C4.4A by ADAM10 and ADAM17 contributes to tumor progression
17912244 we consider C4.4A as a candidate diagnostic marker in colorectal cancer, which possibly can be detected in body fluids
17849475 Overexpression of C4.4A is associated with invasion and metastasis of esophageal squamous cell carcinoma
17706320 High tumour cell C4.4A expression is associated with shorter survival for non-small cell lung cancer patients.
12592373 hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan

AA Sequence

MDPARKAGAQAMIWTAGWLLLLLLRGGAQALECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVET      1 - 70
IHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQDRCNAKLNLTSRALDPAGNESAYPPNGVEC     71 - 140
YSCVGLSREACQGTSPPVVSCYNASDHVYKGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFT    141 - 210
LSGSCCQGSRCNSDLRNKTYFSPRIPPLVRLPPPEPTTVASTTSVTTSTSAPVRPTSTTKPMPAPTSQTP    211 - 280
RQGVEHEASRDEEPRLTGGAAGHQDRSNSGQYPAKGGPQQPHNKGCVAPTAGLAALLLAVAAGVLL        281 - 346
//

Text Mined References (25)

PMID Year Title
25414274 2015 Expression of the Ly6/uPAR-domain proteins C4.4A and Haldisin in non-invasive and invasive skin lesions.
25293881 2015 The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations.
24935570 2014 Expression of C4.4A is a potential independent prognostic factor for patients with gastric cancer.
23918676 2015 C4.4A highly expressed in HER2-positive human breast cancers may indicate a good prognosis.
23708783 2013 Concurrent expression of C4.4A and Tenascin-C in tumor cells relates to poor prognosis of esophageal squamous cell carcinoma.
22431918 2012 Membrane-bound and exosomal metastasis-associated C4.4A promotes migration by associating with the ?(6)?(4) integrin and MT1-MMP.
22404718 2012 C4.4A is associated with tumor budding and epithelial-mesenchymal transition of colorectal cancer.
20825414 2010 Expression of C4.4A at the invasive front is a novel prognostic marker for disease recurrence of colorectal cancer.
18979631 2008 Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17.
17912244 2007 C4.4A as a candidate marker in the diagnosis of colorectal cancer.
17849475 2008 Altered expression of the urokinase receptor homologue, C4.4A, in invasive areas of human esophageal squamous cell carcinoma.
17706320 2007 Tumour cell expression of C4.4A, a structural homologue of the urokinase receptor, correlates with poor prognosis in non-small cell lung cancer.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16502470 2006 Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16303743 2005 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
15057824 2004 The DNA sequence and biology of human chromosome 19.
15012588 2004 Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
12592373 2003 hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11245483 2001 Identification of genes involved in human urothelial cell-matrix interactions: implications for the progression pathways of malignant urothelium.
11179665 2001 Cloning of the human homologue of the metastasis-associated rat C4.4A.