Tchem LY96 Lymphocyte antigen 96

Protein Summary

Description

Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581). This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q9Y6Y9
• B3Y6A5
• E5RJJ7
• Ly-96

Gene Name

• LY96

Ensembl ID

• ENST00000284818
• ENSP00000284818
• ENSG00000154589
• ENST00000518893
• ENSP00000430533

Symbol

• ESOP1
• MD2
• MD2
• MD-2
• ly-96
• ESOP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.95
disease	0.62
PubMedID	0.59
tissue sample	0.59
biological process	0.57

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Lymphocyte Antigen 96

DTO Classes

Protein / Receptor / Lymphocyte Antigen 96

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 918.22   (req: < 5)

Gene RIFs: 119   (req: <= 3)

Antibodies: 458   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 918.22   (req: >= 5)

Gene RIFs: 119   (req: > 3)

Antibodies: 458   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0