Tbio LXN Latexin

Protein Summary

Description

Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation. This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q9BS40
• Q96PN2
• Q9NQS6

Gene Name

• LXN

Ensembl ID

• ENST00000264265
• ENSP00000264265
• ENSG00000079257

Symbol

• ECI
• TCI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.92
kinase perturbation	0.88
gene perturbation	0.85
cell type or tissue	0.74
disease perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.25   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 555   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.25   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 555   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0