Tclin LTK Leukocyte tyrosine kinase receptor

Protein Summary

Description

Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• P29376
• A6NNJ8
• B4DL89
• E9PFX4

Gene Name

• LTK

Ensembl ID

• ENST00000263800
• ENSP00000263800
• ENSG00000062524
• ENST00000355166
• ENSP00000347293
• ENST00000453182
• ENSP00000392196

Symbol

• TYK1
• TYK1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.97
protein domain	0.97
ligand (protein) perturbation	0.83
co-expressed gene	0.79
biological process	0.65

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Alk Family / Leukocyte Tyrosine Kinase Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.98   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 276   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.98   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4