You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
LTB4R
Leukotriene B4 receptor 1

Protein Summary
Description
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345363
  • ENSP00000307445
  • ENSG00000213903
  • ENST00000396782
  • ENSP00000380002
  • ENST00000396789
  • ENSP00000380008
  • ENST00000646659
  • ENSP00000495785
  • ENSG00000285456
  • ENST00000646739
  • ENSP00000494730
  • ENST00000647085
  • ENSP00000495466

Symbol
  • BLT
  • BLT1
  • BLTR
  • CMKRL1
  • GPR16
  • P2RY7
  • BLT1
  • BLTR
  • P2Y7
  • GPR16
  • LTBR1
  • P2RY7
  • CMKRL1
  • LTB4R1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.71
PubMedID
0.7
gene perturbation
0.64
transcription factor perturbation
0.61
ligand (chemical)
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.81   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 506   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.81   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 506   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 201
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1