Property Summary

NCBI Gene PubMed Count 22
PubMed Score 51.00
PubTator Score 35.17

Knowledge Summary


No data available


  Differential Expression (15)

Disease log2 FC p
osteosarcoma 1.928 1.3e-04
ependymoma -1.400 1.1e-04
glioblastoma -2.000 2.4e-03
sonic hedgehog group medulloblastoma -3.300 2.5e-09
atypical teratoid / rhabdoid tumor -2.700 1.4e-04
medulloblastoma, large-cell -3.200 2.7e-07
primary pancreatic ductal adenocarcinoma 1.130 4.1e-03
non-small cell lung cancer -1.318 1.7e-12
intraductal papillary-mucinous adenoma (... -1.800 1.1e-02
intraductal papillary-mucinous neoplasm ... -2.400 1.6e-02
lung cancer -1.500 4.8e-02
pediatric high grade glioma -1.800 6.3e-04
primary Sjogren syndrome 1.400 2.9e-04
ovarian cancer -4.400 2.6e-18
pituitary cancer 2.800 3.3e-07

Protein-protein Interaction (1)

Gene RIF (12)

26844274 A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men
24885297 The tumor suppressor function of LSAMP is most likely exerted by reducing the proliferation rate of the tumor cells, possibly by indirectly upregulating one or more of the genes HES1, CTAG2 or KLF10.
24491686 The results showed significant allelic and haplotypic associations between LSAMP gene and schizophrenia.
22892717 This study presents the first evidence of a possible role of LSAMP gene in mood and anxiety disorders in humans.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19724913 Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma.
19441093 results show that LSAMP is a novel candidate tumor suppressor gene in osteosarcomas
18433483 LSAMP might play a role in pathoaetiology of suicidal behaviour but further studies are needed to understand its exact contribution
18433483 Observational study of gene-disease association. (HuGE Navigator)
18318786 Single nucleotide polymorphisms of LSAMP is associated with the pathogenesis of coronary artery disease.
18318786 Observational study of gene-disease association. (HuGE Navigator)
18268500 proteomic assessments of membrane microdomains in prefrontal cortex and validation in two brain series, strongly implicates LAMP, STXBP1 and BASP1 in schizophreina and supports the view of a neuritic and synaptic dysfunction in the neuropathology

AA Sequence


Text Mined References (23)

PMID Year Title
26844274 2015 A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men.
25158072 2015 Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.
24962325 2014 Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
24885297 2014 Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model.
24491686 2014 Associations between polymorphisms of LSAMP gene and schizophrenia.
23532449 2013 Limbic system associated membrane protein as a potential target for neuropsychiatric disorders.
22892717 2012 Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder.
21982860 2012 A secreted protein microarray platform for extracellular protein interaction discovery.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19724913 2009 Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma.
19441093 2009 LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization.
19349973 2009 Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
18433483 2008 Association of limbic system-associated membrane protein (LSAMP) to male completed suicide.
18318786 2008 Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease.
18268500 2009 Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression.
17452356 2007 Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15146195 2004 Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14667507 2003 The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9615236 1998 Assignment of the gene encoding the limbic system-associated membrane protein (LAMP) to mouse chromosome 16B5 and human chromosome 3q13.2-q21.
8666243 1996 cDNA cloning and structural analysis of the human limbic-system-associated membrane protein (LAMP).