| Tchem | Leucine-rich repeat serine/threonine-protein kinase 2 |
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 455 |
| NCBI Gene PubMed Count | 767 |
| PubMed Score | 1241.37 |
| PubTator Score | 1294.44 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Carcinoma, Renal Cell | 124 | 0.0 | 0.0 |
| Endometriosis | 540 | 0.0 | 0.0 |
| Nerve Degeneration | 121 | 0.0 | 0.0 |
| PARKINSON DISEASE 8, AUTOSOMAL DOMINANT | 1 | 0.0 | 0.0 |
| Parkinson Disease | 64 | 0.0 | 0.0 |
| Parkinsonian Disorders | 56 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 2.2e-42 |
| non-small cell lung cancer | 2890 | 1.1e-25 |
| tuberculosis | 2010 | 2.0e-07 |
| ovarian cancer | 8520 | 3.8e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 3.6e-05 |
| medulloblastoma, large-cell | 6241 | 6.1e-05 |
| acute quadriplegic myopathy | 1158 | 1.1e-04 |
| lung adenocarcinoma | 2716 | 1.2e-04 |
| Astrocytoma, Pilocytic | 3081 | 1.7e-04 |
| osteosarcoma | 7950 | 5.0e-04 |
| ulcerative colitis | 1819 | 5.3e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 6.9e-04 |
| Pick disease | 1894 | 1.2e-03 |
| group 3 medulloblastoma | 4104 | 1.2e-03 |
| diabetes mellitus | 1728 | 4.6e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 6.2e-03 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 6.4e-03 |
| invasive ductal carcinoma | 2951 | 7.6e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Parkinson's disease | 392 | 7.964 | 4.0 |
| Crohn's disease | 321 | 3.232 | 1.6 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neurodegenerative disease | 414 | 0.0 | 4.0 |
| Disease | log2 FC | p |
|---|---|---|
| ovarian cancer | -1.600 | 3.8e-07 |
| acute quadriplegic myopathy | 2.021 | 1.1e-04 |
| Astrocytoma, Pilocytic | 1.700 | 1.7e-04 |
| atypical teratoid / rhabdoid tumor | -2.200 | 3.6e-05 |
| diabetes mellitus | -1.200 | 4.6e-03 |
| group 3 medulloblastoma | -2.300 | 1.2e-03 |
| intraductal papillary-mucinous adenoma (... | -1.800 | 6.9e-04 |
| intraductal papillary-mucinous carcinoma... | -1.700 | 6.2e-03 |
| invasive ductal carcinoma | -1.100 | 7.6e-03 |
| lung adenocarcinoma | -1.300 | 1.2e-04 |
| lung carcinoma | -5.300 | 2.2e-42 |
| medulloblastoma, large-cell | -3.200 | 6.1e-05 |
| mucosa-associated lymphoid tissue lympho... | 2.146 | 6.4e-03 |
| non-small cell lung cancer | -4.006 | 1.1e-25 |
| osteosarcoma | -3.506 | 5.0e-04 |
| Pick disease | -1.300 | 1.2e-03 |
| tuberculosis | 3.200 | 2.0e-07 |
| ulcerative colitis | 1.700 | 5.3e-04 |
CHEMBL3641807
pKi 7.54
CHEMBL2170016
pIC50 7.54
CHEMBL3122120
pIC50 7.54
CHEMBL3651763
pKi 7.54
CHEMBL3651802
pKi 7.54
CHEMBL2347823
pIC50 7.55
CHEMBL2347805
pIC50 7.55
CHEMBL3641893
pKi 7.55
CHEMBL3797298
pKi 7.55
CHEMBL3641836
pKi 7.55
CHEMBL2326726
pIC50 7.55
CHEMBL3393354
pIC50 7.55
CHEMBL3393343
pIC50 7.55
CHEMBL3641832
pKi 7.56
CHEMBL3651732
pKi 7.57
CHEMBL2333126
pIC50 7.57
CHEMBL2178127
pIC50 7.57
CHEMBL2347811
pIC50 7.57
CHEMBL2178137
pIC50 7.57
CHEMBL3694809
pKi 7.57
MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNIHVPLLIVLDS 1 - 70 YMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKMLTVHNASVNLSVIGLKTLD 71 - 140 LLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLGCKALHVLFERVSEEQLTEFVENKDYMILLS 141 - 210 ALTNFKDEEEIVLHVLHCLHSLAIPCNNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLG 211 - 280 NFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWL 281 - 350 EACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN 351 - 420 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTV 421 - 490 MKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQ 491 - 560 KCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKI 561 - 630 LVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFA 631 - 700 KVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQD 701 - 770 VRKALTISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA 771 - 840 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNS 841 - 910 ISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSDSISSLASE 911 - 980 REYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSF 981 - 1050 PSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKIS 1051 - 1120 GICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPE 1121 - 1190 AILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI 1191 - 1260 PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAV 1261 - 1330 PYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREE 1331 - 1400 FYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKIT 1401 - 1470 KELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKN 1471 - 1540 VPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQI 1541 - 1610 LTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI 1611 - 1680 ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLV 1681 - 1750 GSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGE 1751 - 1820 EHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSF 1821 - 1890 GSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQ 1891 - 1960 QDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIK 1961 - 2030 TSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYG 2031 - 2100 CAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLG 2101 - 2170 CGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEK 2171 - 2240 MTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESTNST 2241 - 2310 ERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKT 2311 - 2380 EKLCGLIDCVHFLREVMVKENKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYN 2381 - 2450 FCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEK 2451 - 2520 MRRTSVE 2521 - 2527 //
