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Tdark
LRRCC1
Leucine-rich repeat and coiled-coil domain-containing protein 1

Protein Summary
Description
Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis. This gene encodes a centrosomal protein that maintains the structural integrity of the centrosome and plays a key role in mitotic spindle formation. The encoded protein contains an N-terminal leucine-rich repeat domain and a C-terminal coiled-coil domain. It associates with the centrosome throughout the cell cycle and accumulates on the mitotic centrosome. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360375
  • ENSP00000353538
  • ENSG00000133739
  • ENST00000414626
  • ENSP00000394695

Symbol
  • CLERC
  • KIAA1764
  • SAP2
  • VFL1
  • CLERC
  • CLERK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
cell line
0.79
tissue sample
0.67
gene perturbation
0.65
cell type or tissue
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.85   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.85   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0