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Tbio
LRRC7
Leucine-rich repeat-containing protein 7

Protein Summary
Description
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000035383
  • ENSP00000035383
  • ENSG00000033122

Symbol
  • KIAA1365
  • LAP1
  • DENSIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.76
cell type or tissue
0.72
cell line
0.61
trait
0.61
phenotype
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.09   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.09   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0