Property Summary

NCBI Gene PubMed Count 23
PubMed Score 23.06
PubTator Score 23.38

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (10)

Gene RIF (12)

PMID Text
24563334 polymorphisms and haplotypes in the LRRC4 may have a role in pituitary adenoma in a Chinese population
24404152 Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4.
22834685 LRRC4 inhibited the miR-185 pathway function in glioma
21809374 Potentially, modulation of LRRC4 or STMN1 expression may be useful for design of new therapies for the intervention of glioma
21435336 As a glioma suppressor, LRRC4 inhibits the endogenous expression of small regulatory microRNA hsa-miR-381 and decreases cell proliferation and tumor growth in cultured glioma cells.
18976507 Methylation-mediated inactivation of LRRC4 is a frequent and glioma-specific event.
17541939 LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downgrading pleiotropic cytokine responses.
16941076 LRRC4 may be a negative regulator of the RPTP-zeta receptor, and contribute to suppressing the invasion ability of gliomas cells
16723503 LRRC4 plays a major role in suppressing U251 cell proliferation by regulating the extracellular signal-regulated kinase (ERK)/Akt/NF-kappaBp65, STAT3, and JNK2/c-Jun pathways.
16215635 these studies represent the first cDNA array analysis of the effects of LRRC4 on the involvement of different neurobiological genes in U251MG glioblastoma cells and provide new insights into the function of LRRC4 in glioma
16188120 LRRC4 gene might be involved in tumor suppression by restraining DNA synthesis and nucleoli organizer regions-associated proteins.
15967442 LRRC4 may play an important role in maintaining normal function and suppressing tumorigenesis in the central nervous system.

AA Sequence

MKLLWQVTVHHHTWNAILLPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVP      1 - 70
QGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPS     71 - 140
GAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKD    141 - 210
MPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSS    211 - 280
LPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQC    281 - 350
SAPFIMDAPRDLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTG    351 - 420
VYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTSTGYQPAYTTS    421 - 490
TTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTV    491 - 560
TAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGNSLHPT    561 - 630
VTTISEPYIIQTHTKDKVQETQI                                                   631 - 653
//

Text Mined References (24)

PMID Year Title
24563334 2014 LRRC4 haplotypes are associated with pituitary adenoma in a Chinese population.
24404152 2014 Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4.
22834685 2012 LRRC4 inhibits glioma cell growth and invasion through a miR-185-dependent pathway.
21946559 2011 Structural basis for cell surface patterning through NetrinG-NGL interactions.
21809374 2011 LRRC4 inhibits the proliferation of human glioma cells by modulating the expression of STMN1 and microtubule polymerization.
21435336 2011 Interaction of hsa-miR-381 and glioma suppressor LRRC4 is involved in glioma growth.
18976507 2008 Promoter hypermethylation-mediated inactivation of LRRC4 in gliomas.
17541939 2008 LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses.
16959974 2006 The consensus coding sequences of human breast and colorectal cancers.
16941076 2006 LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression.
16723503 2006 LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway.
16215635 2005 Profiling of differentially expressed genes in LRRC4 overexpressed glioblastoma cells by cDNA array.
16188120 2005 [Function of a novel brain-specific gene LRRC4].
16077900 2005 Study of a novel brain relatively specific gene LRRC4 involved in glioma tumorigenesis suppression using the Tet-on system.
15967442 2005 Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14595443 2003 The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
12969517 2003 Expression of LRRC4 has the potential to decrease the growth rate and tumorigenesis of glioblastoma cell line U251.
12690205 2003 Human chromosome 7: DNA sequence and biology.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10964959 2000 Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.