| Tdark | Leucine-rich repeat-containing protein 34 |
Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ependymoma | 4679 | 2.8e-11 |
| nasopharyngeal carcinoma | 1058 | 2.2e-06 |
| pituitary cancer | 1972 | 8.4e-06 |
| osteosarcoma | 7950 | 9.9e-06 |
| ductal carcinoma in situ | 1745 | 2.5e-03 |
| invasive ductal carcinoma | 2951 | 1.5e-02 |
| fibroadenoma | 559 | 4.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| interstitial lung disease | 298 | 0.0 | 3.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Ciliopathy | 71 | 3.147 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| ductal carcinoma in situ | -1.200 | 2.5e-03 |
| ependymoma | 2.900 | 2.8e-11 |
| fibroadenoma | -1.100 | 4.3e-02 |
| invasive ductal carcinoma | -1.100 | 1.5e-02 |
| nasopharyngeal carcinoma | -1.900 | 2.2e-06 |
| osteosarcoma | -1.674 | 9.9e-06 |
| pituitary cancer | 1.300 | 8.4e-06 |
MGSSREAARAPARSPAWASTQASTPGAALAVQRESPESGLQKHYSNLCMEKSQKINPFILHILQEVDEEI 1 - 70 KKGLAAGITLNIAGNNRLVPVERVTGEDFWILSKILKNCLYINGLDVGYNLLCDVGAYYAAKLLQKQLNL 71 - 140 IYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEEST 141 - 210 VHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLE 211 - 280 VIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEAT 281 - 350 CIAYSDLIQMGCLKPDNTDVEPFVVDGRVYLAEVSNGLKKHYYWTSTYGESYDHSSNAGFALVPVGQQP 351 - 419 //
