Tbio LRRC25 Leucine-rich repeat-containing protein 25

Protein Summary

Description

Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164). Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.

Uniprot Accession IDs

• Q8N386
• Q6IQ00
• Q8N9A5

Gene Name

• LRRC25

Ensembl ID

• ENST00000339007
• ENSP00000340983
• ENSG00000175489
• ENST00000595840
• ENSP00000472290

Symbol

• MAPA
• MAPA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.6
tissue sample	0.6
histone modification site profile	0.53
transcription factor	0.47
transcription factor binding site profile	0.43

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.8   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 294   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.8   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0