Leucine-rich repeat-containing protein 20

Property Summary

NCBI Gene PubMed Count	13
PubMed Score	0.21

PubTator Score	0.27

Knowledge Summary

Patent

No data available

TINX Plot

Disease (1)

Expression Atlas

Disease	Target Count	P-value
lung adenocarcinoma	2716	1.0e-10
juvenile dermatomyositis	1187	1.7e-08
acute quadriplegic myopathy	1158	9.7e-07
malignant mesothelioma	3232	3.2e-06
psoriasis	6694	7.4e-04

Differential Expression (5)

Disease	log2 FC	p
acute quadriplegic myopathy	-1.824	9.7e-07
juvenile dermatomyositis	-1.021	1.7e-08
lung adenocarcinoma	1.500	1.0e-10
malignant mesothelioma	1.100	3.2e-06
psoriasis	1.300	7.4e-04

Muscle - Skeletal 17,778

Brain - Frontal Cortex (BA9) 18,069

Brain - Cortex 18,039

Testis 18,518

Brain - Cerebellum 17,983

Brain - Cerebellar Hemisphere 18,015

Colon - Sigmoid 18,089

Brain - Anterior cingulate cortex (BA24) 17,989

Brain - Nucleus accumbens (basal ganglia... 18,024

Pituitary 18,147

Heart - Atrial Appendage 17,896

Esophagus - Mucosa 18,076

Vagina 17,834

Brain - Amygdala 18,006

Brain - Caudate (basal ganglia) 18,001

Liver 18,071

Uterus 17,618

Brain - Hypothalamus 18,169

Heart - Left Ventricle 18,006

Cells - EBV-transformed lymphocytes 18,186

Esophagus - Muscularis 18,017

Brain - Putamen (basal ganglia) 17,863

Brain - Hippocampus 18,011

Brain - Substantia nigra 17,981

Esophagus - Gastroesophageal Junction 18,000

Ovary 17,971

Prostate 18,213

Nerve - Tibial 18,007

Brain - Spinal cord (cervical c-1) 17,973

Thyroid 18,024

Adrenal Gland 18,071

Stomach 17,879

Artery - Coronary 17,949

Artery - Aorta 17,896

Adipose - Visceral (Omentum) 17,937

Spleen 17,614

Artery - Tibial 17,631

Adipose - Subcutaneous 18,110

Skin - Sun Exposed (Lower leg) 17,968

Cells - Transformed fibroblasts 17,577

Minor Salivary Gland 18,005

Small Intestine - Terminal Ileum 17,954

Breast - Mammary Tissue 18,103

Skin - Not Sun Exposed (Suprapubic) 18,081

Lung 18,057

Kidney - Cortex 17,329

Colon - Transverse 17,825

Pancreas 18,123

Whole Blood 17,439

Fetal Heart 9,228

Adult Esophagus 4,936

Fetal Brain 7,866

Adult Spinal Cord 7,594

Fetal Testis 7,955

Fetal Ovary 9,118

Adult Prostate 8,952

CD4 Cells 7,773

Adult Heart 6,506

Adult Pancreas 9,168

Adult Testis 10,836

Adult Retina 10,115

Adult Rectum 8,022

Adult Colon 7,915

Adult Liver 9,113

Adult Frontal Cortex 9,048

Adult Urinary Bladder 7,592

CD8 Cells 9,840

Brain

Colon

Frontal lobe

Heart

Liver

Esophagus

Ovary

Pancreas

Prostate gland

Rectum

Retina

Spinal cord

Testis

Urinary bladder

BTO:0004410

BTO:0005453

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

liver 14,587

lung 16,312

lymph node 15,833

ovary 15,408

pancreas 14,070

parathyroid gland 14,769

placenta 15,937

prostate 16,460

rectum 15,705

salivary gland 14,981

seminal vesicle 15,918

skeletal muscle 14,011

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

tonsil 15,400

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

See source...

Synonym

Accession	Q8TCA0 Q5T6D4 Q5T6D6 Q9NVA6 Q9NVG3
Symbols

Gene

LRRC20

Ortholog (15)

Species	Source	Disease
Anole lizard 10,588	Inparanoid OMA EggNOG
Platypus 5,703	Inparanoid OMA EggNOG
Zebrafish 9,726	Inparanoid OMA
Xenopus 10,468	Inparanoid OMA EggNOG
Fruitfly 3,050	Inparanoid EggNOG
C. elegans 3,179	OMA EggNOG
Chimp 14,140	OMA EggNOG
Mouse 16,570	Inparanoid OMA EggNOG
Macaque 12,761	Inparanoid OMA EggNOG
Dog 15,073	Inparanoid OMA EggNOG
Rat 15,117	Inparanoid OMA EggNOG
Cow 15,320	Inparanoid OMA EggNOG
Horse 14,252	Inparanoid OMA EggNOG
Opossum 12,230	Inparanoid EggNOG
Pig 10,168	OMA EggNOG

UniProt Keyword (6)

Complete proteome 20,231

Reference proteome 20,231

Repeat 4,916

Alternative splicing 10,528

Phosphoprotein 8,216

Leucine-rich repeat 312

Compartment GO Term (3)

Cytosol 6,686

Nucleoplasm 5,077

cellular_component 18,320

GWAS Trait (4)

Cognitive decline rate in late mild cogn... 51

Caudate activity during reward 18

Obsessive-compulsive disorder or autism ... 9

Brain connectivity 7

HCA RNA Cell Line (56)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493

See all...

Protein-protein Interaction (5)

POTEI ACTB ACTA2 ACTBL2 SUGT1

Gene RIF (3)

AA Sequence

MLKKMGEAVARVARKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFM      1 - 70
TTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKL     71 - 140
AAMPALRSINLRFNPLNAEVRVIAPPLIKFDMLMSPEGARAPLP                              141 - 184
//

Text Mined References (14)

Summary
Details

	PMID	Year	Title

Tdark Leucine-rich repeat-containing protein 20 Add to cart View Collections Empty Collection