Tbio LRRC17 Leucine-rich repeat-containing protein 17

Protein Summary

Description

Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity).

Uniprot Accession IDs

• Q8N6Y2
• Q13288
• Q6UWA7
• Q75MG5

Gene Name

• LRRC17

Ensembl ID

• ENST00000249377
• ENSP00000249377
• ENSG00000128606
• ENST00000339431
• ENSP00000344242

Symbol

• P37NB
• P37NB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
gene perturbation	0.61
small molecule perturbation	0.57
cell type or tissue	0.53
PubMedID	0.52

Protein Classes

PANTHER Classes

Protein / Receptor / Leucine-rich Repeat-containing Protein 17

Protein / Extracellular Matrix Protein / Leucine-rich Repeat-containing Protein 17

DTO Classes

Protein / Receptor / Leucine-rich Repeat-containing Protein 17

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 50   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0