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Tdark Low-density lipoprotein receptor-related protein 10

Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).

This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]

 Comments

Property Summary

NCBI Gene PubMed Count 15
PubMed Score 1.66
PubTator Score 3.63

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Expression

  Differential Expression (19)

Disease log2 FC p
Multiple myeloma 1.204 2.8e-04
malignant mesothelioma -2.100 7.4e-08
posterior fossa group A ependymoma 1.400 4.0e-12
psoriasis 1.300 1.3e-04
glioblastoma 1.700 2.7e-02
osteosarcoma -1.759 7.2e-07
astrocytoma 2.400 2.9e-03
medulloblastoma, large-cell -1.700 4.9e-05
intraductal papillary-mucinous carcinoma... 1.100 4.4e-03
intraductal papillary-mucinous neoplasm ... 1.300 3.0e-03
pediatric high grade glioma 1.300 2.2e-05
group 4 medulloblastoma -1.200 2.1e-03
pilocytic astrocytoma 1.500 3.5e-08
subependymal giant cell astrocytoma 1.716 1.1e-02
nasopharyngeal carcinoma -1.100 1.9e-05
spina bifida -1.500 3.5e-02
mucosa-associated lymphoid tissue lympho... 1.062 8.1e-03
ovarian cancer 1.800 1.1e-04
Down syndrome 1.200 2.7e-03

Synonym

Accession Q7Z4F1 A8K4R5 D3DS31 O95882 Q14CK7 Q86T02 Q8NCZ4 Q9HC42 Q9UG33 LRP-10
Symbols LRP9
LRP-10
MST087
MSTP087

Gene

LRP10

PANTHER Protein Class (2)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (15)

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 GO Function (1)

 GO Component (3)

 GO Process (3)

 Compartment GO Term (13)

 HCA RNA Cell Line (56)

See all...

 CSPA Cell Line (8)

Pathway (7)

Gene RIF (3)

PMID Text
25492683 In Mayer-Rokitansky-Kuster-Hauser syndrome in monoztgotic twins, LRP10 was identified as one of the candidate genes.
22734645 Increased expression of LRP10 in human neuroblastoma SH-SY5Y cells induces the accumulation of mature APP in the Golgi and reduces its presence at the cell surface and its processing into Abeta.
20093106 LRP10 may interfere with the formation of the beta-catenin/TCF complex and/or its binding to target DNA in the nucleus, and that the extracellular domain of LRP10 is critical for inhibition of the canonical Wnt/beta-catenin signaling pathway.

AA Sequence 

MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVT      1 - 70
IRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQDWLMC     71 - 140
LQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSPGYTH    141 - 210
LASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLS    211 - 280
GQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDE    281 - 350
EDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDG    351 - 420
QPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQ    421 - 490
QAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGGPGARRRQRGRLMRRLVRRL    491 - 560
RRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLPSASTSPA    561 - 630
PTTVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPG    631 - 700
VWVAEAEDEPLLT                                                             701 - 713
//

Text Mined References (20)

PMID Year Title
25492683 2015 Mayer-Rokitansky-Küster-Hauser syndrome discordance in monozygotic twins: matrix metalloproteinase 14, low-density lipoprotein receptor-related protein 10, extracellular matrix, and neoangiogenesis genes identified as candidate genes in a tissue-specific mosaicism.
22734645 2012 LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease.
20093106 2010 The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/beta-catenin signaling pathway.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19946888 2010 Defining the membrane proteome of NK cells.
18691976 2008 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
16751776 2006 A germline-specific class of small RNAs binds mammalian Piwi proteins.
16341674 2005 Transcriptome analysis of human gastric cancer.
15498874 2004 Large-scale cDNA transfection screening for genes related to cancer development and progression.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
12766061 2003 Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11123907 2000 A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro.
9110174 1997 Large-scale concatenation cDNA sequencing.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.
8619474 1996 A "double adaptor" method for improved shotgun library construction.