Tdark | Low-density lipoprotein receptor-related protein 10 |
Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).
This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]
This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]
Comments
Disease | Target Count | P-value |
---|---|---|
Astrocytoma, Pilocytic | 3081 | 2.4e-08 |
malignant mesothelioma | 3232 | 7.4e-08 |
ovarian cancer | 8520 | 1.4e-07 |
osteosarcoma | 7950 | 7.2e-07 |
nasopharyngeal carcinoma | 1058 | 1.9e-05 |
pediatric high grade glioma | 1064 | 2.2e-05 |
psoriasis | 6694 | 1.3e-04 |
Multiple myeloma | 1332 | 2.8e-04 |
medulloblastoma, large-cell | 6241 | 5.7e-04 |
group 4 medulloblastoma | 1855 | 2.2e-03 |
Down syndrome | 499 | 2.7e-03 |
astrocytoma | 1146 | 2.9e-03 |
intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.0e-03 |
intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 4.4e-03 |
mucosa-associated lymphoid tissue lymphoma | 484 | 8.1e-03 |
subependymal giant cell astrocytoma | 2287 | 1.1e-02 |
glioblastoma | 5792 | 2.7e-02 |
ependymoma | 4679 | 2.9e-02 |
spina bifida | 1074 | 3.5e-02 |
Disease | log2 FC | p |
---|---|---|
astrocytoma | 2.400 | 2.9e-03 |
Astrocytoma, Pilocytic | 1.500 | 2.4e-08 |
Down syndrome | 1.200 | 2.7e-03 |
ependymoma | 1.300 | 2.9e-02 |
glioblastoma | 1.700 | 2.7e-02 |
group 4 medulloblastoma | -1.100 | 2.2e-03 |
intraductal papillary-mucinous carcinoma... | 1.100 | 4.4e-03 |
intraductal papillary-mucinous neoplasm ... | 1.300 | 3.0e-03 |
malignant mesothelioma | -2.100 | 7.4e-08 |
medulloblastoma, large-cell | -1.200 | 5.7e-04 |
mucosa-associated lymphoid tissue lympho... | 1.062 | 8.1e-03 |
Multiple myeloma | 1.204 | 2.8e-04 |
nasopharyngeal carcinoma | -1.100 | 1.9e-05 |
osteosarcoma | -1.759 | 7.2e-07 |
ovarian cancer | -1.400 | 1.4e-07 |
pediatric high grade glioma | 1.300 | 2.2e-05 |
psoriasis | 1.300 | 1.3e-04 |
spina bifida | -1.500 | 3.5e-02 |
subependymal giant cell astrocytoma | 1.716 | 1.1e-02 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVT 1 - 70 IRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQDWLMC 71 - 140 LQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSPGYTH 141 - 210 LASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLS 211 - 280 GQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDE 281 - 350 EDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDG 351 - 420 QPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQ 421 - 490 QAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGGPGARRRQRGRLMRRLVRRL 491 - 560 RRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLPSASTSPA 561 - 630 PTTVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPG 631 - 700 VWVAEAEDEPLLT 701 - 713 //