| Tdark | Low-density lipoprotein receptor-related protein 10 |
Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).
This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]
This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Astrocytoma, Pilocytic | 3081 | 2.4e-08 |
| malignant mesothelioma | 3232 | 7.4e-08 |
| ovarian cancer | 8520 | 1.4e-07 |
| osteosarcoma | 7950 | 7.2e-07 |
| nasopharyngeal carcinoma | 1058 | 1.9e-05 |
| pediatric high grade glioma | 1064 | 2.2e-05 |
| psoriasis | 6694 | 1.3e-04 |
| Multiple myeloma | 1332 | 2.8e-04 |
| medulloblastoma, large-cell | 6241 | 5.7e-04 |
| group 4 medulloblastoma | 1855 | 2.2e-03 |
| Down syndrome | 499 | 2.7e-03 |
| astrocytoma | 1146 | 2.9e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.0e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 4.4e-03 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 8.1e-03 |
| subependymal giant cell astrocytoma | 2287 | 1.1e-02 |
| glioblastoma | 5792 | 2.7e-02 |
| ependymoma | 4679 | 2.9e-02 |
| spina bifida | 1074 | 3.5e-02 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | 2.400 | 2.9e-03 |
| Astrocytoma, Pilocytic | 1.500 | 2.4e-08 |
| Down syndrome | 1.200 | 2.7e-03 |
| ependymoma | 1.300 | 2.9e-02 |
| glioblastoma | 1.700 | 2.7e-02 |
| group 4 medulloblastoma | -1.100 | 2.2e-03 |
| intraductal papillary-mucinous carcinoma... | 1.100 | 4.4e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.300 | 3.0e-03 |
| malignant mesothelioma | -2.100 | 7.4e-08 |
| medulloblastoma, large-cell | -1.200 | 5.7e-04 |
| mucosa-associated lymphoid tissue lympho... | 1.062 | 8.1e-03 |
| Multiple myeloma | 1.204 | 2.8e-04 |
| nasopharyngeal carcinoma | -1.100 | 1.9e-05 |
| osteosarcoma | -1.759 | 7.2e-07 |
| ovarian cancer | -1.400 | 1.4e-07 |
| pediatric high grade glioma | 1.300 | 2.2e-05 |
| psoriasis | 1.300 | 1.3e-04 |
| spina bifida | -1.500 | 3.5e-02 |
| subependymal giant cell astrocytoma | 1.716 | 1.1e-02 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVT 1 - 70 IRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQDWLMC 71 - 140 LQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSPGYTH 141 - 210 LASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLS 211 - 280 GQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDE 281 - 350 EDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDG 351 - 420 QPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQ 421 - 490 QAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGGPGARRRQRGRLMRRLVRRL 491 - 560 RRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLPSASTSPA 561 - 630 PTTVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPG 631 - 700 VWVAEAEDEPLLT 701 - 713 //
