Tbio LRCH4 Leucine-rich repeat and calponin homology domain-containing protein 4

Protein Summary

Description

This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75427
• A4D2D5
• Q8WV85
• Q96ID0

Gene Name

• LRCH4

Ensembl ID

• ENST00000310300
• ENSP00000309689
• ENSG00000077454

Symbol

• LRN
• LRRN1
• LRRN4
• LRN
• LRRN1
• LRRN4
• PP14183

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.99
cell type or tissue	0.84
transcription factor binding site profile	0.76
transcription factor	0.74
interacting protein	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.75   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.75   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0