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  6. Lysophosphatidic acid receptor 2

Tchem Lysophosphatidic acid receptor 2

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

Ligand Count 21
NCBI Gene PubMed Count 58
PubMed Score 89.31
PubTator Score 86.06

Knowledge Summary

Patent (14,243)

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.5
Disease Target Count Z-score Confidence
Cancer 2499 3.229 1.6

Expression

  Differential Expression (6)

Disease log2 FC p
atypical teratoid / rhabdoid tumor 1.100 1.1e-03
group 3 medulloblastoma 2.200 4.3e-08
intraductal papillary-mucinous adenoma (... 1.200 3.3e-03
medulloblastoma, large-cell 1.100 1.0e-03
osteosarcoma -2.135 1.6e-04
primitive neuroectodermal tumor 1.300 8.1e-03

Synonym

Accession Q9HBW0 O00543 O43431 LPA receptor 2
Symbols EDG4
LPA2
EDG-4
LPA-2

Gene

LPAR2

PANTHER Protein Class (2)

PDB

4P0C  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (13)

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 GO Function (3)

 GO Component (3)

 GO Process (3)

 Compartment GO Term (14)

 MGI Phenotype (5)

 HCA RNA Cell Line (56)

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Pathway (16)

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Protein-protein Interaction (2)

LGALS3   HBB  

Ligand (21)

Structure of CHEMBL2335052

CHEMBL2335052
pEC50 7.00

Structure of CHEMBL432813

CHEMBL432813
pIC50 7.05

Structure of CHEMBL117723

CHEMBL117723
pIC50 7.10

Structure of CHEMBL333335

CHEMBL333335
pIC50 7.13

Structure of CHEMBL3322508

CHEMBL3322508
pEC50 7.22

Structure of CHEMBL119873

CHEMBL119873
pIC50 7.23

Structure of CHEMBL117715

CHEMBL117715
pIC50 7.24

Structure of CHEMBL119413

CHEMBL119413
pIC50 7.26

Structure of CHEMBL3322507

CHEMBL3322507
pEC50 7.30

Structure of CHEMBL118815

CHEMBL118815
pIC50 7.38

Structure of CHEMBL118860

CHEMBL118860
pIC50 7.40

Structure of CHEMBL119354

CHEMBL119354
pIC50 7.44

Structure of CHEMBL118783

CHEMBL118783
pIC50 7.48

Structure of CHEMBL331054

CHEMBL331054
pIC50 7.50

Structure of CHEMBL117021

CHEMBL117021
pEC50 7.54

Structure of CHEMBL119256

CHEMBL119256
pIC50 7.59

Structure of CHEMBL332667

CHEMBL332667
pIC50 7.64

Structure of CHEMBL441826

CHEMBL441826
pIC50 7.75

Structure of CHEMBL119440

CHEMBL119440
pIC50 7.82

Structure of CHEMBL119116

CHEMBL119116
pIC50 8.18

Gene RIF (35)

AA Sequence 

MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYL      1 - 70
LGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHS     71 - 140
RLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTR    141 - 210
IFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYF    211 - 280
LLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDST    281 - 350
L//

Text Mined References (58)

PMID Year Title