| Tchem | Lysophosphatidic acid receptor 2 |
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| group 3 medulloblastoma | 4104 | 4.3e-08 |
| osteosarcoma | 7950 | 1.6e-04 |
| medulloblastoma, large-cell | 6241 | 1.0e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.1e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 3.3e-03 |
| primitive neuroectodermal tumor | 3035 | 8.1e-03 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 1.100 | 1.1e-03 |
| group 3 medulloblastoma | 2.200 | 4.3e-08 |
| intraductal papillary-mucinous adenoma (... | 1.200 | 3.3e-03 |
| medulloblastoma, large-cell | 1.100 | 1.0e-03 |
| osteosarcoma | -2.135 | 1.6e-04 |
| primitive neuroectodermal tumor | 1.300 | 8.1e-03 |
| Accession | Q9HBW0 O00543 O43431 LPA receptor 2 |
| Symbols |
EDG4 LPA2 EDG-4 LPA-2 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
CHEMBL2335052
pEC50 7.00
CHEMBL432813
pIC50 7.05
CHEMBL117723
pIC50 7.10
CHEMBL333335
pIC50 7.13
CHEMBL3322508
pEC50 7.22
CHEMBL119873
pIC50 7.23
CHEMBL117715
pIC50 7.24
CHEMBL119413
pIC50 7.26
CHEMBL3322507
pEC50 7.30
CHEMBL118815
pIC50 7.38
CHEMBL118860
pIC50 7.40
CHEMBL119354
pIC50 7.44
CHEMBL118783
pIC50 7.48
CHEMBL331054
pIC50 7.50
CHEMBL117021
pEC50 7.54
CHEMBL119256
pIC50 7.59
CHEMBL332667
pIC50 7.64
CHEMBL441826
pIC50 7.75
CHEMBL119440
pIC50 7.82
CHEMBL119116
pIC50 8.18
MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYL 1 - 70 LGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHS 71 - 140 RLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTR 141 - 210 IFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYF 211 - 280 LLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDST 281 - 350 L//
