Tdark LONRF3 LON peptidase N-terminal domain and RING finger protein 3

Protein Summary

Description

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Multiple alternatively spliced transcript variants have been suggested, but their full length natures are not clear. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q496Y0
• Q5JPN6
• Q8NB00
• Q9H647

Gene Name

• LONRF3

Ensembl ID

• ENST00000304778
• ENSP00000307732
• ENSG00000175556
• ENST00000371628
• ENSP00000360690
• ENST00000481285
• ENSP00000435426

Symbol

• RNF127
• RNF127

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
transcription factor perturbation	0.91
PubMedID	0.72
molecular function	0.67
gene perturbation	0.65

Protein Classes

PANTHER Classes

Protein / ... / Ubiquitin-protein Ligase / Lon Peptidase N-terminal Domain And Ring Finger Protein 3

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Lon Peptidase N-terminal Domain And Ring Finger Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.02   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.02   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0