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Tbio
LMBRD1
Probable lysosomal cobalamin transporter

Protein Summary
Description
Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. (Microbial infection) Isoform 3: May play a role in the assembly of hepatitis delta virus (HDV). This gene encodes a lysosomal membrane protein that may be involved in the transport and metabolism of cobalamin. This protein also interacts with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus. Mutations in this gene are associated with the vitamin B12 metabolism disorder termed, homocystinuria-megaloblastic anemia complementation type F.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370570
  • ENSP00000359602
  • ENSG00000168216
  • ENST00000370577
  • ENSP00000359609
  • ENST00000647964
  • ENSP00000496784
  • ENST00000648168
  • ENSP00000498178
  • ENST00000648394
  • ENSP00000497302
  • ENST00000648743
  • ENSP00000497135
  • ENST00000649028
  • ENSP00000498034
  • ENST00000649679
  • ENSP00000497387
  • ENST00000649918
  • ENSP00000497487
  • ENST00000649934
  • ENSP00000497690
  • ENST00000650035
  • ENSP00000497703
  • ENST00000650107
  • ENSP00000497124

Symbol
  • C6orf209
  • NESI
  • NESI
  • LMBD1
  • MAHCF
  • C6orf209
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
disease perturbation
0.9
cellular component
0.81
transcription factor binding site profile
0.81
pathway
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.5   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.5   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0