Tbio LMAN2L VIP36-like protein

Protein Summary

Description

May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53. This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• Q9H0V9
• B4DSH3
• D3DXH6
• Q53GV3
• Q53S67
• Q63HN6
• Q8NBQ6
• Q9BQ14

Gene Name

• LMAN2L

Ensembl ID

• ENST00000264963
• ENSP00000264963
• ENSG00000114988
• ENST00000377079
• ENSP00000366280

Symbol

• VIPL
• VIPL
• MRT52

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
histone modification site profile	0.77
virus perturbation	0.72
kinase perturbation	0.71
cell type or tissue	0.65

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Vip36-like Protein

DTO Classes

Protein / Transporter / Vip36-like Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.31   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 55   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.31   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0