Tbio LITAF Lipopolysaccharide-induced tumor necrosis factor-alpha factor

Protein Summary

Description

Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation (PubMed:23166352). Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades (PubMed:23166352). Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes (PubMed:23166352). Probably plays a role in regulating protein degradation via its interaction with NEDD4 (PubMed:15776429). May also contribute to the regulation of gene expression in the nucleus (PubMed:10200294, PubMed:15793005). Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005). May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:10200294, PubMed:15793005). Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• Q99732
• D3DUG1
• G5E9K0
• Q05DW0
• Q9C0L6
• LPS-induced TNF-alpha factor

Gene Name

• LITAF

Ensembl ID

• ENST00000339430
• ENSP00000340118
• ENSG00000189067
• ENST00000381810
• ENSP00000371231
• ENST00000413364
• ENSP00000397958
• ENST00000570904
• ENSP00000459138
• ENST00000571688
• ENSP00000459533
• ENST00000574763
• ENSP00000461813
• ENST00000576036
• ENSP00000461667
• ENST00000620789
• ENSP00000481589
• ENST00000622633
• ENSP00000483114

Symbol

• PIG7
• SIMPLE
• PIG7
• SIMPLE
• TP53I7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
transcription factor perturbation	1
virus perturbation	1
biological process	0.85
kinase perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Lipopolysaccharide-induced Tumor Necrosis Factor-alpha Factor

DTO Classes

Protein / Transcription Factor / Lipopolysaccharide-induced Tumor Necrosis Factor-alpha Factor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.93   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 272   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.93   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0