Tchem Hepatic triacylglycerol lipase

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Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]

Comments

Property Summary

Ligand Count	281
NCBI Gene PubMed Count	307
PubMed Score	388.96

PubTator Score	759.70

Knowledge Summary

Patent

No data available

TINX Plot

Disease (8)

Disease	Target Count	Z-score	Confidence
Diabetes Mellitus, Type 2	142	0.0	0.0
HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 12	1	0.0	0.0
Hepatic lipase deficiency	1	0.0	0.0
Hyperemia	13	0.0	0.0
Hyperlipidemias	17	0.0	0.0
Hyperlipoproteinemia Type II	12	0.0	0.0
Hyperlipoproteinemias	5	0.0	0.0
Insulin Resistance	72	0.0	0.0
Lipid Metabolism, Inborn Errors	6	0.0	0.0

Disease	Target Count
Angina Pectoris	32
Autosomal recessive predisposition	1442
Cholesteryl Ester Transfer Protein Deficiency	3
Coronary artery disease, premature	6
Diabetes Mellitus, Non-Insulin-Dependent	145
Eruptive xanthoma	3
HEPATIC LIPASE DEFICIENCY (disorder)	1
Hypercholesterolemia, Familial	23
Hyperlipidemia	43
Hypertriglyceridemia result	37

Disease	Target Count	P-value
atypical teratoid / rhabdoid tumor	5112	7.4e-07
primitive neuroectodermal tumor	3035	4.4e-04
glioblastoma	5792	4.6e-04
medulloblastoma, large-cell	6241	3.7e-03
pancreatic ductal adenocarcinoma liver metastasis	1962	3.7e-03
group 3 medulloblastoma	4104	9.5e-03

Disease	Target Count	Z-score	Confidence
Carcinoma	11493	0.0	0.7

Disease	Target Count	Z-score	Confidence
Lipid metabolism disorder	114	4.174	2.1
Amyotrophic lateral sclerosis	451	0.0	0.7
Cardiovascular system disease	246	0.0	3.0
Macular degeneration	65	0.0	3.0
Metabolic syndrome X	52	0.0	3.0
Peripheral vascular disease	87	0.0	3.0
Type 2 diabetes mellitus	272	0.0	1.6
Vascular disease	319	0.0	2.0
lung cancer	4740	0.0	0.8

Disease	Target Count	Z-score	Confidence
Age related macular degeneration	72	4.237	2.1

Disease	Target Count	Z-score	Confidence
Status Epilepticus	98	4.012	2.0
Coronary artery disease	268	3.955	2.0
Atherosclerosis	291	3.371	1.7
diabetes mellitus	1728	3.177	1.6

Disease	Target Count
Diabetes Mellitus, Noninsulin-Dependent	31

Differential Expression (6)

Disease	log2 FC	p
atypical teratoid / rhabdoid tumor	-1.600	7.4e-07
glioblastoma	-1.300	4.6e-04
group 3 medulloblastoma	-1.200	9.5e-03
medulloblastoma, large-cell	-1.600	3.7e-03
pancreatic ductal adenocarcinoma liver m...	-2.492	3.7e-03
primitive neuroectodermal tumor	-1.600	4.4e-04

Liver 18,071

Nerve - Tibial 18,007

Kidney - Cortex 17,329

Pituitary 18,147

Cells - Transformed fibroblasts 17,577

Brain - Spinal cord (cervical c-1) 17,973

Vagina 17,834

Thyroid 18,024

Spleen 17,614

Adipose - Subcutaneous 18,110

Skin - Sun Exposed (Lower leg) 17,968

Artery - Coronary 17,949

Ovary 17,971

Esophagus - Gastroesophageal Junction 18,000

Skin - Not Sun Exposed (Suprapubic) 18,081

Whole Blood 17,439

Heart - Atrial Appendage 17,896

Small Intestine - Terminal Ileum 17,954

Brain - Frontal Cortex (BA9) 18,069

Brain - Substantia nigra 17,981

Esophagus - Muscularis 18,017

Brain - Cortex 18,039

Stomach 17,879

Breast - Mammary Tissue 18,103

Adipose - Visceral (Omentum) 17,937

Brain - Anterior cingulate cortex (BA24) 17,989

Esophagus - Mucosa 18,076

Lung 18,057

Brain - Hippocampus 18,011

Brain - Amygdala 18,006

Pancreas 18,123

Prostate 18,213

Artery - Tibial 17,631

Uterus 17,618

Artery - Aorta 17,896

Colon - Sigmoid 18,089

Colon - Transverse 17,825

Brain - Hypothalamus 18,169

Testis 18,518

Minor Salivary Gland 18,005

Brain - Cerebellar Hemisphere 18,015

Brain - Cerebellum 17,983

Heart - Left Ventricle 18,006

Brain - Caudate (basal ganglia) 18,001

Brain - Putamen (basal ganglia) 17,863

Brain - Nucleus accumbens (basal ganglia... 18,024

Cells - EBV-transformed lymphocytes 18,186

Adrenal Gland 18,071

Muscle - Skeletal 17,778

Fetal Liver 8,402

Adult Liver 9,113

Fetal Gut 8,640

Gut

Liver

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

liver 14,587

lung 16,312

lymph node 15,833

ovary 15,408

pancreas 14,070

placenta 15,937

prostate 16,460

rectum 15,705

salivary gland 14,981

seminal vesicle 15,918

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

tonsil 15,400

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Kidney 1,299

Liver 5,008

Thymus 427

See source...

Blood plasma 163

Liver 1,045

See source...

Synonym

Accession	P11150 A2RUB4 A8K9B6 O43571 P78529 Q99465 HL
Symbols	HL HTGL LIPH HDLCQ12

Gene

LIPC

PANTHER Protein Class (2)

storage protein 18

esterase 32

Ortholog (13)

Species	Source	Disease
Chimp 14,136	OMA EggNOG
Mouse 16,567	Inparanoid OMA EggNOG
Macaque 12,758	Inparanoid OMA EggNOG
Dog 15,069	Inparanoid OMA EggNOG
Rat 15,112	Inparanoid OMA
Cow 15,316	OMA EggNOG
Horse 14,249	Inparanoid OMA EggNOG
Opossum 12,223	Inparanoid EggNOG
Pig 10,164	Inparanoid OMA EggNOG
Anole lizard 10,585	Inparanoid OMA EggNOG
Chicken 7,823	Inparanoid OMA
Zebrafish 9,725	Inparanoid OMA EggNOG
Xenopus 10,463	Inparanoid OMA EggNOG

UniProt Keyword (13)

Complete proteome 20,231

Polymorphism 12,194

Reference proteome 20,231

Disease mutation 2,804

Glycoprotein 4,623

Hydrolase 1,654

Lipid metabolism 432

Secreted 2,041

Signal 3,561

Direct protein sequencing 2,872

See all...

GO Function (5)

heparin binding 161

phospholipase activity 11

low-density lipoprotein particle binding 14

triglyceride lipase activity 16

apolipoprotein binding 16

GO Component (4)

extracellular region 1,833

extracellular space 1,380

endoplasmic reticulum lumen 291

high-density lipoprotein particle 24

GO Process (13)

cholesterol homeostasis 60

high-density lipoprotein particle remode... 17

reverse cholesterol transport 17

cholesterol metabolic process 64

fatty acid biosynthetic process 39

chylomicron remnant clearance 8

regulation of lipoprotein lipase activit... 9

triglyceride homeostasis 25

triglyceride catabolic process 25

low-density lipoprotein particle remodel... 13

See all...

Compartment GO Term (33)

Cell 16,178

Cell part 16,177

Chylomicron 40

Cytoplasm 10,983

Cytoplasmic part 9,247

Endomembrane system 4,237

Endoplasmic reticulum 2,001

Endoplasmic reticulum lumen 303

Endoplasmic reticulum part 1,359

Extracellular region 2,732

Extracellular region part 1,627

Extracellular space 1,124

Intracellular 14,108

Intracellular membrane-bounded organelle 10,341

Intracellular organelle 12,025

See all...

OMIM Phenotype (3)

Phenotype: [High density lipoprotein cho... 2

Diabetes mellitus, noninsulin-dependent 5

Hepatic lipase deficiency 2

MGI Phenotype (3)

endocrine-exocrine gland phenotype 2,293

homeostasis-metabolism phenotype 4,747

reproductive system phenotype 1,999

GWAS Trait (20)

Metabolite levels 87

Blood metabolite levels 157

Obesity-related traits 569

Schizophrenia 533

HDL cholesterol 116

HDL cholesterol levels 66

Cholesterol, total 123

Total cholesterol levels 65

Hemoglobin concentration 112

Alzheimer's disease (cognitive decline) 40

See all...

HCA RNA Cell Line (52)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

CACO-2 15,436

See all...

Pathway (18)

Metabolic pathways 1,263

Glycerolipid metabolism 61

Cholesterol metabolism 51

http://pathwaycommons.org/pc2/Pathway_cb... 14

http://identifiers.org/panther.pathway/P... 2

http://identifiers.org/smpdb/SMP00039 11

http://identifiers.org/smpdb/SMP00187 11

http://identifiers.org/smpdb/SMP00529 11

http://identifiers.org/smpdb/SMP00530 11

Transport of small molecules 717

See all...

Protein-protein Interaction (2)

ATP4A MTMR1

Ligand (281)

CHEMBL3677599
pIC50 6.00

CHEMBL3677644
pIC50 6.00

CHEMBL3677594
pIC50 6.02

CHEMBL3677471
pIC50 6.03

CHEMBL3677643
pIC50 6.04

CHEMBL3672622
pIC50 6.04

CHEMBL3677490
pIC50 6.04

CHEMBL3677586
pIC50 6.05

CHEMBL3677624
pIC50 6.06

CHEMBL3677468
pIC50 6.08

CHEMBL3682496
pIC50 6.08

CHEMBL3682487
pIC50 6.10

CHEMBL3677589
pIC50 6.12

CHEMBL3677593
pIC50 6.20

CHEMBL3677466
pIC50 6.20

CHEMBL3677600
pIC50 6.21

CHEMBL3672659
pIC50 6.21

CHEMBL3677569
pIC50 6.22

CHEMBL3682461
pIC50 6.24

CHEMBL3682468
pIC50 6.26

See all 281 ligands...

Gene RIF (314)

AA Sequence

MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQGCQIRINHPD      1 - 70
TLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLV     71 - 140
GKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLS    141 - 210
PDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHE    211 - 280
RSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFK    281 - 350
VYHYQFKIQFINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKW    351 - 420
ENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQEKIFVKCEIK    421 - 490
SKTSKRKIR                                                                 491 - 499
//

Text Mined References (311)

Summary
Details

	PMID	Year	Title

Tchem Hepatic triacylglycerol lipase Add to cart View Collections Empty Collection

Property Summary

Knowledge Summary

Patent

No data available

TINX Plot

Disease (8)

Expression

Differential Expression (6)

Synonym

Gene

PANTHER Protein Class (2)

Ortholog (13)

UniProt Keyword (13)

GO Function (5)

GO Component (4)

GO Process (13)

Compartment GO Term (33)

OMIM Phenotype (3)

MGI Phenotype (3)

GWAS Trait (20)

HCA RNA Cell Line (52)

Pathway (18)

Protein-protein Interaction (2)

Ligand (281)

Gene RIF (314)

AA Sequence

Text Mined References (311)

Tchem Hepatic triacylglycerol lipase

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