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Tbio
LILRB5
Leukocyte immunoglobulin-like receptor subfamily B member 5

Protein Summary
Description
May act as receptor for class I MHC antigens. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316219
  • ENSP00000320390
  • ENSG00000105609
  • ENST00000345866
  • ENSP00000263430
  • ENST00000449561
  • ENSP00000406478
  • ENST00000610764
  • ENSP00000479022
  • ENSG00000277414
  • ENST00000614318
  • ENSP00000483649
  • ENSG00000278437
  • ENST00000615429
  • ENSP00000482404
  • ENSG00000274311
  • ENST00000615837
  • ENSP00000478835
  • ENST00000616618
  • ENSP00000478912
  • ENST00000616805
  • ENSP00000483502
  • ENSG00000273991
  • ENST00000617355
  • ENSP00000483481
  • ENST00000619608
  • ENSP00000479413
  • ENST00000620714
  • ENSP00000480909
  • ENST00000621193
  • ENSP00000482062
  • ENST00000621867
  • ENSP00000481263
  • ENST00000622596
  • ENSP00000482535

Symbol
  • LIR8
  • LIR8
  • CD85C
  • LIR-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.6
cell line
0.54
tissue
0.49
protein complex
0.41
protein domain
0.41


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.8   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.8   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0