| Tbio | Leukemia inhibitory factor |
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Abortion, Spontaneous | 109 | 0.0 | 0.0 |
| Cardiomegaly | 116 | 0.0 | 0.0 |
| Embryo Loss | 7 | 0.0 | 0.0 |
| Female Urogenital Diseases | 18 | 0.0 | 0.0 |
| Infertility, Female | 28 | 0.0 | 0.0 |
| Non-alcoholic Fatty Liver Disease | 42 | 0.0 | 0.0 |
| Polycystic ovary syndrome | 360 | 0.0 | 0.0 |
| Weight Loss | 24 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Delirium | 10 |
| Depressive disorder | 409 |
| Female infertility | 30 |
| Mental Depression | 333 |
| Spontaneous abortion | 113 |
| Weight decreased | 103 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 8.7e-65 |
| Astrocytoma, Pilocytic | 3081 | 1.2e-09 |
| malignant mesothelioma | 3232 | 1.4e-05 |
| ependymoma | 4679 | 9.0e-05 |
| adult high grade glioma | 3801 | 1.2e-04 |
| glioblastoma | 5792 | 2.9e-04 |
| lung cancer | 4740 | 3.2e-04 |
| pancreatic cancer | 2398 | 6.4e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 7.9e-04 |
| interstitial cystitis | 2312 | 8.7e-04 |
| inflammatory breast cancer | 286 | 2.2e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 3.6e-03 |
| pituitary cancer | 1972 | 7.3e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.2e-02 |
| subependymal giant cell astrocytoma | 2287 | 3.1e-02 |
| chronic rhinosinusitis | 512 | 3.3e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.400 | 1.2e-04 |
| Astrocytoma, Pilocytic | 2.000 | 1.2e-09 |
| atypical teratoid / rhabdoid tumor | 1.300 | 3.6e-03 |
| chronic rhinosinusitis | -1.010 | 3.3e-02 |
| ependymoma | 1.400 | 9.0e-05 |
| glioblastoma | 1.600 | 2.9e-04 |
| inflammatory breast cancer | -1.200 | 2.2e-03 |
| interstitial cystitis | 1.100 | 8.7e-04 |
| intraductal papillary-mucinous neoplasm ... | 2.100 | 7.9e-04 |
| lung cancer | -2.800 | 3.2e-04 |
| malignant mesothelioma | -1.400 | 1.4e-05 |
| pancreatic cancer | 1.200 | 6.4e-04 |
| pancreatic ductal adenocarcinoma liver m... | 1.104 | 1.2e-02 |
| pituitary cancer | -1.100 | 7.3e-03 |
| psoriasis | -1.600 | 8.7e-65 |
| subependymal giant cell astrocytoma | 1.482 | 3.1e-02 |
