Tbio LCN1 Lipocalin-1

Protein Summary

Description

Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket. This gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• P31025
• Q5T8A1

Gene Name

• LCN1

Ensembl ID

• ENST00000263598
• ENSP00000263598
• ENSG00000160349
• ENST00000371781
• ENSP00000360846

Symbol

• VEGP
• TP
• TLC
• PMFA
• VEGP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	0.67
interacting protein	0.61
protein domain	0.58
cell type or tissue	0.56
cell line	0.55

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Lipocalin-1

Protein / Isomerase / Lipocalin-1

DTO Classes

Protein / Enzyme / Isomerase / Lipocalin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.94   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 234   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.94   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0