Property Summary

NCBI Gene PubMed Count 24
PubMed Score 16.47
PubTator Score 21.44

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count
psoriasis 6685
Disease Target Count P-value
diabetes mellitus 1663 1.2e-03
Disease Target Count Z-score Confidence
Psoriatic arthritis 85 3.777 1.9

Gene RIF (26)

PMID Text
24566688 Our data suggest that The LCE deletion, previously identified in patients with psoriasis, is not of a major importance in the development of PsA in Tunisian patients
24485035 No evidence of association was seen between the LCE3C_LCE3B-del and psoriasis in 34 patients from 7 multiplex Tunisian families. No epistasic effect was found between the deletion and PSORS1 locus.
23631431 Our meta-analysis demonstrates a significant association between psoriasis and the LCE3C_LCE3B-del polymorphism in Europeans and Asians, but no association with psoriatic arthritis.
22926764 The LCE3C_LCE3B-del might play a role in familial psoriasis in the Tunisian population.
22512642 Paediatric-onset psoriasis is associated with .......... LCE3C_LCE3B deletion
22384135 LCE3C_LCE3B-del is a common risk factor for (auto)immune diseases
22048733 results suggest that the Koebner phenomenon in psoriasis is unlikely to be dependent on the LCE3B/C genotype
21995181 A deletion of LCE3B and LCE3C genes may promote the development of allergic contact dermatitis
21711330 The findings indicate that the LCE3C_LCE3B-del is an important risk factor in the pathogenesis of psoriasis and that the LCE3C_LCE3B-del does not show an epistatic effect with the HLA-Cw6 allele on susceptibility to psoriasis in the northern Chinese
21628307 This study provides evidence for an association between LCE3C_LCE3B-del and RA in non-Caucasian populations, and SNPs rs4112788 and rs4085613 tagging LCE3C_LCE3B-del were novel susceptibility factors for SLE.
21509048 Our study confirms an association between the deletion of LCE3C and LCE3B and psoriasis in a Chinese population.
21435436 LCE3B/C deletion may have a role in psoriasis
21400479 LCE3C_LCE3B deletion is a susceptibility factor for Psoriatic arthritis, confirming the existence of a shared risk factor involving the epidermal skin barrier in autoimmune disorders.
21107349 the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European, Chinese and Mongolian populations.
20624365 Meta-analysis of gene-disease association. (HuGE Navigator)
20376060 no genetic association between LCE3B and LCE3C deletions and atopic dermatitis
20376060 Observational study of gene-disease association. (HuGE Navigator)
20331852 work suggested that homozygosity for a common LCE3C_LCE3B deletion contributes to the risk of developing chronic plaque type Psoriasis without psoriatic arthritis
20331852 Observational study of gene-disease association. (HuGE Navigator)
20213803 we have verified a pleiotropic effect of a common genetic risk factor (LCE3C_LCE3B-del) for autoimmune diseases that is involved in both psoriasis and rheumatoid arthritis
20213803 Observational study of gene-disease association. (HuGE Navigator)
20016497 study confirms the recently published finding that the deletion of the two LCE genes is a susceptibility factor for psoriasis vulgaris with dosage effect
20016497 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19169253 LCE3C_LCE3B-del shows epistatic effects with the HLA-Cw6 allele on the development of psoriasis.
19169253 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
15854049 paper describing nomenclature changes and expression in range of tissues and in response to UV

AA Sequence

MSCQQNQQQCQPLPKCPSPKCPPKSSAQCLPPASSCCAPRPGCCGGPSSEGGCCLSHHRCCRSHRCRRQS      1 - 70
SNSCDRGSGQQDGASDCGYGSGGCC                                                  71 - 95
//

Text Mined References (24)

PMID Year Title
24566688 2014 Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients.
24485035 2014 Failure to find evidence for deletion of LCE3C and LCE3B genes at PSORS4 contributing to psoriasis susceptibility in Tunisian families.
23631431 2013 Association between the LCE3C_LCE3B deletion polymorphism and susceptibility to psoriasis: a meta-analysis of published studies.
22926764 2012 Association analysis of LCE3C-LCE3B deletion in Tunisian psoriatic population.
22512642 2012 Paediatric-onset psoriasis is associated with ERAP1 and IL23R loci, LCE3C_LCE3B deletion and HLA-C*06.
22384135 2012 A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C.
22048733 2012 Koebner phenomenon in psoriasis is not associated with deletion of late cornified envelope genes LCE3B and LCE3C.
21995181 2011 Deletion of the late cornified envelope genes LCE3B and LCE3C may promote chronic hand eczema with allergic contact dermatitis.
21711330 2011 Deletion of LCE3C and LCE3B genes is associated with psoriasis in a northern Chinese population.
21628307 2011 Deletion of LCE3C_LCE3B is associated with rheumatoid arthritis and systemic lupus erythematosus in the Chinese Han population.
21509048 2011 Deletion of the late cornified envelope genes LCE3C and LCE3B is associated with psoriasis in a Chinese population.
21435436 2011 Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups.
21400479 2011 Deletion of LCE3C and LCE3B is a susceptibility factor for psoriatic arthritis: a study in Spanish and Italian populations and meta-analysis.
21107349 2011 Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6.
20624365 2010 LCE3C_LCE3B-del genotype and psoriasis: a summative meta-analysis.
20376060 2010 Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis.
20331852 2010 Mutation analysis of the LCE3B/LCE3C genes in Psoriasis.
20213803 2010 Deletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis.
20016497 2010 Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors.
19169253 2009 Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
15854049 2005 Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11698679 2001 Differentially expressed late constituents of the epidermal cornified envelope.